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Hurd/St. Andrews Library
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Synergistic Antitumor Effects of Immune Cell-Viral Biotherapy.
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- Author(s): Thorne, Steve H.; Negrin, Robert S.; Contag, Christopher H.
- Source:
Science. 3/24/2006, Vol. 311 Issue 5768, p1780-1784. 5p. 1 Color Photograph, 3 Graphs. - Source:
- Additional Information
- Subject Terms:
- Abstract: Targeted biological therapies hold tremendous potential for treatment of cancer, yet their use has been limited by constraints on delivery and effective tumor targeting. We combined an immune effector cell population [cytokine-induced killer (CIK) cells] with an oncolytic viral therapy to achieve directed delivery to, and regression of, tumors in both immunodeficient and immunocompetent mouse models. Preinfection of CIK cells with modified vaccinia virus resulted in a prolonged eclipse phase with the virus remaining hidden until interaction with the tumor. Whole-body imaging revealed that the cells retained their ability to traffic to and to infiltrate the tumor effectively before releasing the virus. These results illustrate the potential of combining biotherapeutics for synergistic effects that more effectively treat cancer. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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