Gel formulations for treatment of the ophthalmic complications in cystinosis.

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  • Author(s): Buchan B;Buchan B; Kay G; Heneghan A; Matthews KH; Cairns D
  • Source:
    International journal of pharmaceutics [Int J Pharm] 2010 Jun 15; Vol. 392 (1-2), pp. 192-7. Date of Electronic Publication: 2010 Apr 09.
  • Publication Type:
    Journal Article; Research Support, Non-U.S. Gov't
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7804127 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3476 (Electronic) Linking ISSN: 03785173 NLM ISO Abbreviation: Int J Pharm Subsets: MEDLINE
    • Publication Information:
      Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press.
    • Subject Terms:
      Acrylic Resins/*chemistry ; Cornea/*drug effects ; Corneal Diseases/*drug therapy ; Cysteamine/*administration & dosage ; Cystinosis/*complications ; Drug Carriers/*chemistry; Adhesiveness ; Animals ; Cattle ; Corneal Diseases/etiology ; Corneal Diseases/metabolism ; Cysteamine/chemistry ; Cysteamine/therapeutic use ; Cystinosis/metabolism ; Drug Compounding ; Gels ; Hydrogen-Ion Concentration ; In Vitro Techniques ; Molecular Structure ; Phenylalanine/chemistry ; Rheology ; Solubility
    • Abstract:
      Nephropathic cystinosis is a rare autosomal recessive disease characterised by raised lysosomal levels of cystine in the cells of all organs. It is treated by regular administration of the aminothiol, cysteamine. Corneal crystal deposition is one of the most troublesome complications affecting patients and requires the hourly administration of cysteamine eye drops. In an attempt to reduce this frequency and improve the treatment, the preparation and evaluation of cysteamine containing Carbomer gel is reported. The results demonstrated that a weak gel network was formed at low shear-stress, the bioadhesion of the gel was increased with inclusion of a cysteamine derivative (e.g. mean force of 0.067N compared to 0.107N with compound included) and first-order release from the gel was observed. In conclusion these results offer the possibility to formulate cysteamine in an ocular applicable gel formulation.
      (Copyright 2010 Elsevier B.V. All rights reserved.)
    • Accession Number:
      0 (Acrylic Resins)
      0 (Drug Carriers)
      0 (Gels)
      47E5O17Y3R (Phenylalanine)
      4Q93RCW27E (carbopol 940)
      5UX2SD1KE2 (Cysteamine)
    • Publication Date:
      Date Created: 20100413 Date Completed: 20100907 Latest Revision: 20161125
    • Publication Date:
      20240829
    • Accession Number:
      10.1016/j.ijpharm.2010.03.065
    • Accession Number:
      20382212