In vitro inhibitory effect of West African medicinal and food plants on human cytochrome P450 3A subfamily.

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  • Additional Information
    • Source:
      Publisher: Elsevier Sequoia Country of Publication: Ireland NLM ID: 7903310 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7573 (Electronic) Linking ISSN: 03788741 NLM ISO Abbreviation: J Ethnopharmacol Subsets: MEDLINE
    • Publication Information:
      Publication: Limerick : Elsevier Sequoia
      Original Publication: Lausanne, Elsevier Sequoia.
    • Subject Terms:
      Cytochrome P-450 CYP3A/*metabolism ; Drug Interactions/*genetics ; Isoenzymes/*metabolism ; Pharmaceutical Preparations/*metabolism ; Plants, Edible/*metabolism; Africa ; Black People/genetics ; Cytochrome P-450 CYP3A/genetics ; Humans ; Isoenzymes/genetics ; Plants, Edible/genetics
    • Abstract:
      Aim of the Study: In Africa, medicinal plants are used intensively and concomitantly with allopathic medicines in the treatment of opportunity diseases by many patients or by healthy person to prevent diseases. However, there is little information about the interactions between medicines and botanical products used currently in West Africa area. Therefore, the aim of the present investigation is to study the effect of some plant products on CYP3A4, CYP3A5 and CYP3A7, three individual enzymes of CYP3A subfamily, in vitro.
      Materials and Methods: Teas and ethanolic extracts of medicinal, food and co-administered plants were evaluated on CYP3A4, CYP3A5 and CYP3A7 individual enzymes in vitro using fluorometric assays.
      Results: Extracts of adjuvant plants such as Aframomum cuspidatum, and Aframomum melegueta, as well as one medicinal plant (Harrisonia abyssinica) inhibited CYP3A4, CYP3A5 and CYP3A7 activity more than 90%. Phyllanthus amarus showed high inhibition of CYP3A5 and CYP3A7. Food plants (Solanum macrocarpon and Talinum triangulare) inhibited CYP3A4 and CYP3A5 less than 20%.
      Conclusion: These results indicate that plants tested in this study affect in vitro the activity of the main three CYP3A subfamily enzymes. These active plants could interfere with the metabolism at phase I of conventional drugs in vivo as well act as pharmacoenhancers in herbal mixtures.
      (Crown Copyright (c) 2010. Published by Elsevier Ireland Ltd. All rights reserved.)
    • Accession Number:
      0 (Isoenzymes)
      0 (Pharmaceutical Preparations)
      EC 1.14.14.1 (Cytochrome P-450 CYP3A)
    • Publication Date:
      Date Created: 20100130 Date Completed: 20100701 Latest Revision: 20221207
    • Publication Date:
      20240829
    • Accession Number:
      10.1016/j.jep.2010.01.039
    • Accession Number:
      20109542