MiR-150 promotes gastric cancer proliferation by negatively regulating the pro-apoptotic gene EGR2.

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  • Author(s): Wu Q;Wu Q; Jin H; Yang Z; Luo G; Lu Y; Li K; Ren G; Su T; Pan Y; Feng B; Xue Z; Wang X; Fan D
  • Source:
    Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2010 Feb 12; Vol. 392 (3), pp. 340-5. Date of Electronic Publication: 2010 Jan 11.
  • Publication Type:
    Journal Article; Research Support, Non-U.S. Gov't
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE
    • Publication Information:
      Publication: <2002- >: San Diego, CA : Elsevier
      Original Publication: New York, Academic Press.
    • Subject Terms:
      Gene Expression Regulation, Neoplastic*; Apoptosis/*genetics ; Carcinoma/*pathology ; Early Growth Response Protein 2/*genetics ; MicroRNAs/*metabolism ; Stomach Neoplasms/*pathology; Animals ; Base Sequence ; Carcinoma/genetics ; Cell Line, Tumor ; Cell Proliferation ; Humans ; Mice ; Mice, Nude ; MicroRNAs/genetics ; Molecular Sequence Data ; Stomach Neoplasms/genetics
    • Abstract:
      Accumulating evidence suggests small non-coding RNAs (microRNAs) play important roles in human cancer progression. In the present study, we found miR-150 was overexpressed in gastric cancer cell lines and tissues. Ectopic expression of miR-150 promoted tumorigenesis and proliferation of gastric cancer cells. Luciferase reporter assay demonstrated that EGR2 was a direct target of miR-150. Collectively, our study demonstrated that overexpression of miR-150 in gastric cancer could promote proliferation and growth of cancer cells at least partially through directly targeting the tumor-suppressor EGR2, suggesting a potential strategy for the development of miRNA-based treatment of gastric cancer.
    • Accession Number:
      0 (EGR2 protein, human)
      0 (Early Growth Response Protein 2)
      0 (MIRN150 microRNA, human)
      0 (MicroRNAs)
    • Publication Date:
      Date Created: 20100114 Date Completed: 20100323 Latest Revision: 20210427
    • Publication Date:
      20231215
    • Accession Number:
      10.1016/j.bbrc.2009.12.182
    • Accession Number:
      20067763