Antigenic cross-reactivity and immunogenicity of Bothrops venoms from snakes of the Amazon region.

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  • Additional Information
    • Source:
      Publisher: Pergamon Press Country of Publication: England NLM ID: 1307333 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3150 (Electronic) Linking ISSN: 00410101 NLM ISO Abbreviation: Toxicon Subsets: MEDLINE
    • Publication Information:
      Original Publication: Oxford ; New York : Pergamon Press, c1962-
    • Subject Terms:
      Cross Reactions*; Bothrops/*classification ; Crotalid Venoms/*immunology; Animals ; Antibodies, Neutralizing/immunology ; Blotting, Western ; Electrophoresis, Polyacrylamide Gel ; Female ; Lethal Dose 50 ; Male ; Mice ; Rats ; Rats, Wistar ; South America
    • Abstract:
      Snakebites are still a critical public health problem in developing countries or isolated areas. In Brazil, the North Region has a high distribution coefficient worsened by the significant number of eventually unreported cases, due to difficulties in access to health services, to the natural geographic barriers and the vast territory. In the Rio Negro area, the species Bothrops atrox, Bothrops brazili, Lachesis muta muta and Bothriopsis taeniata are thought to be the major species responsible for snakebites. The aim of this study was to qualitatively and quantitatively determine the antigenic cross-reactivity and expression of toxins and the immunogenicity of Bothrops venom species of the Amazon and to evaluate the general efficacy of the therapeutic sera. The in vivo assays demonstrated that the defibrinating activity of B. taeniata venom was absent but that the lethal and hemorrhagic properties were more intense than in the B. atrox venom. The results evidence venom variability among the two B. atrox populations from two distinct Amazonian regions, which may reveal a subjacent speciation process. The results point to new aspects that may guide the improvement of anti-Bothropic therapeutic serum.
      (Copyright 2010 Elsevier Ltd. All rights reserved.)
    • Accession Number:
      0 (Antibodies, Neutralizing)
      0 (Crotalid Venoms)
    • Publication Date:
      Date Created: 20091229 Date Completed: 20100614 Latest Revision: 20100217
    • Publication Date:
      20221213
    • Accession Number:
      10.1016/j.toxicon.2009.12.014
    • Accession Number:
      20036275