Review of hair follicle dermal cells.

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  • Author(s): Yang CC;Yang CC; Cotsarelis G
  • Source:
    Journal of dermatological science [J Dermatol Sci] 2010 Jan; Vol. 57 (1), pp. 2-11.
  • Publication Type:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9011485 Publication Model: Print Cited Medium: Internet ISSN: 1873-569X (Electronic) Linking ISSN: 09231811 NLM ISO Abbreviation: J Dermatol Sci Subsets: MEDLINE
    • Publication Information:
      Original Publication: Amsterdam : Elsevier, c1990-
    • Subject Terms:
      Hair Follicle/*pathology ; Skin/*pathology; AC133 Antigen ; Actins/metabolism ; Alkaline Phosphatase/metabolism ; Animals ; Antigens, CD/biosynthesis ; Bone Morphogenetic Proteins/metabolism ; Glycoproteins/biosynthesis ; Humans ; Models, Biological ; Muscle, Smooth/metabolism ; Peptides ; Regeneration ; Serine Endopeptidases/biosynthesis ; Signal Transduction ; Skin/metabolism ; Versicans/biosynthesis ; Wnt Proteins/metabolism
    • Abstract:
      Hair follicle stem cells in the epithelial bulge are responsible for the continual regeneration of the hair follicle during cycling. The bulge cells reside in a niche composed of dermal cells. The dermal compartment of the hair follicle consists of the dermal papilla and dermal sheath. Interactions between hair follicle epithelial and dermal cells are necessary for hair follicle morphogenesis during development and in hair reconstitution assays. Dermal papilla and dermal sheath cells express specific markers and possess distinctive morphology and behavior in culture. These cells can induce hair follicle differentiation in epithelial cells and are required in hair reconstitution assays either in the form of intact tissue, dissociated freshly prepared cells or cultured cells. This review will focus on hair follicle dermal cells since most therapeutic efforts to date have concentrated on this aspect of the hair follicle, with the idea that enriching hair-inductive dermal cell populations and expanding their number by culture while maintaining their properties, will establish an efficient hair reconstitution assay that could eventually have therapeutic implications.
      (Copyright 2009 Japanese Society for Investigative Dermatology. Published by Elsevier Ireland Ltd. All rights reserved.)
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    • Grant Information:
      R01 AR046837 United States AR NIAMS NIH HHS; R01 AR046837-05 United States AR NIAMS NIH HHS; R01 AR055309 United States AR NIAMS NIH HHS; R01 AR055309-03 United States AR NIAMS NIH HHS
    • Accession Number:
      0 (AC133 Antigen)
      0 (Actins)
      0 (Antigens, CD)
      0 (Bone Morphogenetic Proteins)
      0 (Glycoproteins)
      0 (Peptides)
      0 (Wnt Proteins)
      126968-45-4 (Versicans)
      EC 3.1.3.1 (Alkaline Phosphatase)
      EC 3.4.21.- (CORIN protein, human)
      EC 3.4.21.- (Serine Endopeptidases)
    • Publication Date:
      Date Created: 20091222 Date Completed: 20100525 Latest Revision: 20220408
    • Publication Date:
      20231215
    • Accession Number:
      PMC2818774
    • Accession Number:
      10.1016/j.jdermsci.2009.11.005
    • Accession Number:
      20022473