Regulatory T cells exert checks and balances on self tolerance and autoimmunity.

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  • Author(s): Wing K;Wing K; Sakaguchi S
  • Source:
    Nature immunology [Nat Immunol] 2010 Jan; Vol. 11 (1), pp. 7-13. Date of Electronic Publication: 2009 Dec 17.
  • Publication Type:
    Journal Article; Research Support, Non-U.S. Gov't; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Nature America Inc Country of Publication: United States NLM ID: 100941354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-2916 (Electronic) Linking ISSN: 15292908 NLM ISO Abbreviation: Nat Immunol Subsets: MEDLINE
    • Publication Information:
      Original Publication: New York, NY : Nature America Inc. c2000-
    • Subject Terms:
      Autoimmunity/*immunology ; Self Tolerance/*immunology ; T-Lymphocytes, Regulatory/*immunology; Animals ; Autoimmune Diseases/immunology ; Cytokines/immunology ; Dendritic Cells/immunology ; Humans ; Models, Immunological ; T-Lymphocytes/immunology
    • Abstract:
      Immunological self tolerance is maintained at least in part by regulatory T (T(reg)) cells that actively and dominantly control potentially hazardous self-reactive T cells in the periphery. Antigens that stimulate self-reactive T cells may also activate natural T(reg) cells, thereby maintaining dominant self tolerance. Conversely, genetic anomalies or environmental agents that specifically or predominantly affect T(reg) cells cause or predispose to autoimmunity. With recent advances in our understanding of T(reg) cell development in the thymus and periphery and the molecular mechanism of T(reg) cell-mediated suppression, new ways of treating immunological diseases by targeting T(reg) cells at the cellular and molecular levels are envisaged.
    • Number of References:
      101
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    • Accession Number:
      0 (Cytokines)
    • Publication Date:
      Date Created: 20091218 Date Completed: 20100114 Latest Revision: 20220318
    • Publication Date:
      20240829
    • Accession Number:
      10.1038/ni.1818
    • Accession Number:
      20016504