Effect of feeding Mucuna pruriens on helminth parasite infestation in lambs.

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  • Additional Information
    • Source:
      Publisher: Elsevier Sequoia Country of Publication: Ireland NLM ID: 7903310 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7573 (Electronic) Linking ISSN: 03788741 NLM ISO Abbreviation: J Ethnopharmacol Subsets: MEDLINE
    • Publication Information:
      Publication: Limerick : Elsevier Sequoia
      Original Publication: Lausanne, Elsevier Sequoia.
    • Subject Terms:
      Mucuna* ; Phytotherapy*; Antinematodal Agents/*therapeutic use ; Haemonchiasis/*veterinary ; Levamisole/*therapeutic use ; Plant Preparations/*therapeutic use ; Sheep Diseases/*drug therapy; Animals ; Antinematodal Agents/pharmacology ; Cottonseed Oil ; Diet ; Haemonchiasis/drug therapy ; Haemonchiasis/parasitology ; Haemonchus/drug effects ; Levamisole/pharmacology ; Parasite Egg Count ; Plant Preparations/pharmacology ; Seeds ; Sheep ; Sheep Diseases/parasitology
    • Abstract:
      Ethnopharmacological Relevance: Mucuna pruriens is a tropical legume anecdotally reputed to have anthelmintic properties. This study was conducted to examine the validity of such claims.
      Aim of the Study: The aim of this study was to determine if ingestion of Mucuna seeds reduces helminth parasite infestation in lambs.
      Materials and Methods: Thirty-six Dorper x Katahdin ram lambs were assigned to three treatments, a cottonseed meal based control diet, a diet in which Mucuna replaced cottonseed meal and the control diet with levamisole (7.5mg/kg body weight) administration. All diets were isonitrogenous and isocaloric. The 12 lambs in each treatment were assigned randomly to 4 pens, each containing 3 lambs. Lambs were trickle infected three times per week by gavage with infectious Haemonchus contortus larvae (2000 larvae/lamb) for 3 weeks.
      Results: Levamisole treatment decreased fecal egg counts by 87% and abomasal worm counts by 83%. Mucuna intake did not statistically affect fecal egg counts or abomasal worm counts, though numerical (P>0.10) reductions of 7.4% and 18.1%, respectively were evident. Anemia indicators, feed intake, and lamb growth were unaffected by treatment.
      Conclusions: Levamisole reduced the Haemonchus parasite burden in lambs significantly but feeding Mucuna reduced the burden by levels unlikely to eliminate the clinical effects of parasitism.
      (Copyright 2009 Elsevier Ireland Ltd. All rights reserved.)
    • Accession Number:
      0 (Antinematodal Agents)
      0 (Cottonseed Oil)
      0 (Plant Preparations)
      2880D3468G (Levamisole)
    • Publication Date:
      Date Created: 20091209 Date Completed: 20100806 Latest Revision: 20131121
    • Publication Date:
      20231215
    • Accession Number:
      10.1016/j.jep.2009.12.006
    • Accession Number:
      19969060