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Anchoring novel molecular biomarker responses to traditional responses in fish exposed to environmental contamination.
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- Author(s): Nogueira P;Nogueira P; Pacheco M; Lourdes Pereira M; Mendo S; Rotchell JM
- Source:
Environmental pollution (Barking, Essex : 1987) [Environ Pollut] 2010 May; Vol. 158 (5), pp. 1783-90. Date of Electronic Publication: 2009 Nov 26.- Publication Type:
Evaluation Study; Journal Article; Research Support, Non-U.S. Gov't- Language:
English - Source:
- Additional Information
- Source: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 8804476 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6424 (Electronic) Linking ISSN: 02697491 NLM ISO Abbreviation: Environ Pollut Subsets: MEDLINE
- Publication Information: Original Publication: Barking, Essex, England : Elsevier Applied Science Publishers, c1987-
- Subject Terms: Environmental Exposure*; Biomarkers/*metabolism ; Environmental Monitoring/*methods ; Fish Proteins/*genetics ; Fishes/*genetics ; Water Pollutants, Chemical/*pharmacology; Animals ; Biomarkers/analysis ; Cytochrome P-450 CYP1A1/genetics ; Cytochrome P-450 CYP1A1/metabolism ; Fish Proteins/metabolism ; Fishes/immunology ; Fishes/metabolism ; Gene Expression/drug effects ; Liver/metabolism
- Abstract: The responses of Dicentrarchus labrax and Liza aurata to aquatic pollution were assessed in a contaminated coastal lagoon, using both traditional and novel biomarkers combined. DNA damage, assessed by comet assay, was higher in both fish species from the contaminated sites, whereas levels of cytochrome P450 1A1 gene expression were not significantly altered. The liver histopathological analysis also revealed significant lesions in fish from contaminated sites. Alterations in ras and xpf genes were analysed and additional pollutant-responsive genes were identified. While no alterations were found in ras gene, a downregulation of xpf gene was observed in D. labrax from a contaminated site. Suppression subtractive hybridization applied to D. labrax collected at a contaminated site, revealed altered expression in genes involved in energy metabolism, immune system activity and antioxidant response. The approach and results reported herein demonstrate the utility of anchoring traditional biomarker responses alongside novel biomarker responses.
(Copyright 2009 Elsevier Ltd. All rights reserved.) - Accession Number: 0 (Biomarkers)
0 (Fish Proteins)
0 (Water Pollutants, Chemical)
EC 1.14.14.1 (Cytochrome P-450 CYP1A1) - Publication Date: Date Created: 20091201 Date Completed: 20100729 Latest Revision: 20191210
- Publication Date: 20221213
- Accession Number: 10.1016/j.envpol.2009.11.007
- Accession Number: 19944504
- Source:
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