Effect of intestinal resections on arginine metabolism: practical implications for nutrition support.

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  • Author(s): Crenn P;Crenn P; Cynober L
  • Source:
    Current opinion in clinical nutrition and metabolic care [Curr Opin Clin Nutr Metab Care] 2010 Jan; Vol. 13 (1), pp. 65-9.
  • Publication Type:
    Journal Article; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Lippincott Williams & Wilkins Country of Publication: England NLM ID: 9804399 Publication Model: Print Cited Medium: Internet ISSN: 1473-6519 (Electronic) Linking ISSN: 13631950 NLM ISO Abbreviation: Curr Opin Clin Nutr Metab Care Subsets: MEDLINE
    • Publication Information:
      Publication: 1999- : London : Lippincott Williams & Wilkins
      Original Publication: London ; Philadelphia : Rapid Science Publishers, c1998-
    • Subject Terms:
      Nutritional Support*; Arginine/*metabolism ; Citrulline/*metabolism ; Postoperative Complications/*diet therapy ; Short Bowel Syndrome/*diet therapy; Arginine/administration & dosage ; Citrulline/administration & dosage ; Dietary Supplements ; Humans ; Intestinal Mucosa/metabolism ; Intestines/surgery ; Short Bowel Syndrome/metabolism
    • Abstract:
      Purpose of Review: The present review relates recent developments in the understanding of arginine and citrulline metabolism and complementation after intestinal resection.
      Recent Findings: Arginine metabolism is disturbed after significant intestinal resection, with reduced fluxes and circulating and tissue concentrations. There is also a reduction in citrulline production, a major source of endogenous arginine by enterocyte metabolism. There is evidence to suggest that arginine or citrulline supplementation may be important in this situation.
      Summary: In experimental intestinal resection, arginine availability decreases as intestinal citrulline synthesis decreases. In this setting, there is debate over the efficiency of arginine supplementation on intestinal adaptation, perhaps due to different doses used. In contrast, citrulline, a precursor for arginine synthesis, whether provided enterally or parenterally, is more efficient at 1 g/kg/day than complementation with arginine (at the same dose) in sustaining arginine pools. In addition, citrulline is more effective than arginine in maintaining nitrogen homeostasis. Clinical studies are vital in order to establish the value of citrulline supplementation in short bowel patients.
    • Number of References:
      36
    • Accession Number:
      29VT07BGDA (Citrulline)
      94ZLA3W45F (Arginine)
    • Publication Date:
      Date Created: 20091117 Date Completed: 20100413 Latest Revision: 20181201
    • Publication Date:
      20240829
    • Accession Number:
      10.1097/MCO.0b013e328333c1a8
    • Accession Number:
      19915459