The battlefield of perforin/granzyme cell death pathways.

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  • Author(s): Hoves S;Hoves S; Trapani JA; Voskoboinik I
  • Source:
    Journal of leukocyte biology [J Leukoc Biol] 2010 Feb; Vol. 87 (2), pp. 237-43. Date of Electronic Publication: 2009 Nov 13.
  • Publication Type:
    Journal Article; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Oxford University Press Country of Publication: England NLM ID: 8405628 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1938-3673 (Electronic) Linking ISSN: 07415400 NLM ISO Abbreviation: J Leukoc Biol Subsets: MEDLINE
    • Publication Information:
      Publication: 2023- : Oxford : Oxford University Press
      Original Publication: New York : Alan R. Liss, c1984-
    • Subject Terms:
      Apoptosis/*immunology ; Granzymes/*immunology ; Homeostasis/*immunology ; Immunological Synapses/*immunology ; Perforin/*immunology ; T-Lymphocytes, Cytotoxic/*immunology; Animals ; Humans ; Secretory Vesicles/immunology
    • Abstract:
      A pore-forming protein, PRF, and serine proteases, Grz, are key effector molecules of CL. These toxins are stored within secretory granules, which exocytose their contents in response to immune synapse formation between the CL and virus-infected or transformed target cell. There, PRF and Grz synergize to induce various apoptotic death pathways and to maintain immune homeostasis. Mechanistic aspects of the synergy and apoptotic mechanisms are still not fully understood, and the current review will address some of the hotly debated controversies in the field.
    • Number of References:
      99
    • Accession Number:
      126465-35-8 (Perforin)
      EC 3.4.21.- (Granzymes)
    • Publication Date:
      Date Created: 20091117 Date Completed: 20100225 Latest Revision: 20201212
    • Publication Date:
      20240829
    • Accession Number:
      10.1189/jlb.0909608
    • Accession Number:
      19915166