Urinary L-FABP and anaemia: distinct roles of urinary markers in type 2 diabetes.

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  • Additional Information
    • Source:
      Publisher: Wiley Country of Publication: England NLM ID: 0245331 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2362 (Electronic) Linking ISSN: 00142972 NLM ISO Abbreviation: Eur J Clin Invest Subsets: MEDLINE
    • Publication Information:
      Publication: Oxford : Wiley
      Original Publication: Berlin, New York, Springer-Verlag, on behalf of the European Society for Clinical Investigation.
    • Subject Terms:
      Anemia/*urine ; Diabetes Mellitus, Type 2/*urine ; Diabetic Nephropathies/*urine ; Fatty Acid-Binding Proteins/*urine ; Kidney Failure, Chronic/*urine ; Membrane Glycoproteins/*urine; Aged ; Albumins/analysis ; Anemia/diagnosis ; Anemia/epidemiology ; Biomarkers/urine ; Creatinine/urine ; Diabetes Mellitus, Type 2/complications ; Erythrocyte Count ; Female ; Glucose/metabolism ; Hemoglobins/analysis ; Hepatitis A Virus Cellular Receptor 1 ; Humans ; Kidney Failure, Chronic/epidemiology ; Kidney Function Tests ; Male ; Middle Aged ; Multivariate Analysis ; Neoplasm Proteins/urine ; Receptors, Virus
    • Abstract:
      Background: Urinary liver-type fatty acid binding protein (L-FABP) and kidney injury molecule (KIM)-1, novel urinary biomarkers of renal tubulointerstitial function, have previously been associated with acute ischaemic kidney injury. We studied the clinical significance of urinary L-FABP, KIM-1 and N-acetyl-beta-glucosaminidase (NAG) as potential markers of renal function and chronic ischaemic injury in patients with diabetic nephropathy.
      Material and Methods: A total of 130 type 2 diabetes patients with early diabetic nephropathy and 40 healthy controls were studied. Urinary L-FABP, KIM-1, NAG, albumin excretion rate (AER) and creatinine clearance were obtained from 24-h urine samples, and correlated with measures of red blood cell count, renal function and metabolic control.
      Results: Urinary L-FABP was significantly increased in diabetes patients compared with healthy controls [8.1 (interquartile 0.6-11.6) vs. 2.4 (0.5-3.6) microg/g creatinine, P < 0.001] and correlated with AER (r = 0.276, P = 0.002), creatinine clearance (r = -0.189, P = 0.033) and haemoglobin levels (r = -0.190, P = 0.030). In multivariable linear regression analysis, haemoglobin (beta = -0.247, P = 0.015) and AER (beta = 0.198, P = 0.046) were significant predictors of urinary L-FABP. Prevalent anaemia was independently associated with a 6-fold risk for increased tubulointerstitial kidney damage (upper vs. lower two L-FABP tertiles: OR, 6.06; 95% CI: 1.65-22.23; P = 0.007). Urinary KIM-1 was not significantly associated with kidney function, AER, or measures of red blood cell count while urinary NAG was associated with parameters of glucose control and renal function.
      Conclusions: Different urinary biomarkers may reflect distinct pathophysiological mechanisms of tubulointerstitial damage in early diabetic nephropathy: Urinary L-FABP could be a novel biomarker for chronic intrarenal ischaemia.
    • Accession Number:
      0 (Albumins)
      0 (Biomarkers)
      0 (Fatty Acid-Binding Proteins)
      0 (HAVCR1 protein, human)
      0 (Hemoglobins)
      0 (Hepatitis A Virus Cellular Receptor 1)
      0 (Membrane Glycoproteins)
      0 (NBAS protein, human)
      0 (Neoplasm Proteins)
      0 (Receptors, Virus)
      AYI8EX34EU (Creatinine)
      IY9XDZ35W2 (Glucose)
    • Publication Date:
      Date Created: 20091117 Date Completed: 20100511 Latest Revision: 20201214
    • Publication Date:
      20231215
    • Accession Number:
      10.1111/j.1365-2362.2009.02220.x
    • Accession Number:
      19912308