[Particularities of arginase and NO-synthase pathways of L-arginine metabolism in leucocytes of peripheral blood of rats in conditions of chronic x-ray irradiation].

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  • Author(s): Peretiatko IuV; Sybirna NO
  • Source:
    Ukrains'kyi biokhimichnyi zhurnal (1999 ) [Ukr Biokhim Zh (1999)] 2009 Mar-Apr; Vol. 81 (2), pp. 40-8.
  • Publication Type:
    English Abstract; Journal Article
  • Language:
    Ukrainian
  • Additional Information
    • Source:
      Publisher: Nat︠s︡ionalʹna akademii︠a︡ nauk Ukraïny, Instytut biokhimiï im. O.V. Palladina Country of Publication: Ukraine NLM ID: 101657175 Publication Model: Print Cited Medium: Print NLM ISO Abbreviation: Ukr Biokhim Zh (1999) Subsets: MEDLINE
    • Publication Information:
      Original Publication: Kyïv : Nat︠s︡ionalʹna akademii︠a︡ nauk Ukraïny, Instytut biokhimiï im. O.V. Palladina, 1999-2013.
    • Subject Terms:
      Arginase/*metabolism ; Arginine/*metabolism ; Leukocytes/*radiation effects ; Nitric Oxide Synthase/*metabolism; Animals ; Arginine/administration & dosage ; Arginine/blood ; Leukocytes/enzymology ; Leukocytes/metabolism ; Male ; NG-Nitroarginine Methyl Ester/pharmacology ; Nitric Oxide Synthase/antagonists & inhibitors ; Rats ; Rats, Wistar ; Substrate Specificity ; Time Factors ; X-Rays
    • Abstract:
      Arginine takes part in many metabolic cell processes. It is not only involved in the dynamic cycle of interconversion with prolin and glutamine but also serves as a precursor for protein, nitric oxide, creatine, polyamines, agmatine and urea synthesis. Particularities of arginase and NO-synthase pathways of L-arginine conversion under the X-ray radiation in the leucocytes-radiosensitive cells of peripheral blood, under the per os administration of L-arginine and L-NAME (NG-nitro-L-arginine methyl ester) to rats were detected. It was shown that both L-arginine (arginase and NO-synthase main substrate) and L-NAME (nonspecific inhibitor of NO-synthase) had a positive correct influence on the organism in case of decreasing of NO overproduction under the X-ray radiation.
    • Accession Number:
      94ZLA3W45F (Arginine)
      EC 1.14.13.39 (Nitric Oxide Synthase)
      EC 3.5.3.1 (Arginase)
      V55S2QJN2X (NG-Nitroarginine Methyl Ester)
    • Publication Date:
      Date Created: 20091031 Date Completed: 20100331 Latest Revision: 20150803
    • Publication Date:
      20221213
    • Accession Number:
      19873876