The effects of telmisartan on mechanical responses of left ventricular papillary muscle in rats with streptozotocin-induced diabetes mellitus.

Publisher: Springer Verlag Country of Publication: Germany NLM ID: 9200299 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-5233 (Electronic) Linking ISSN: 09405429 NLM ISO Abbreviation: Acta Diabetol Subsets: MEDLINE

Publication: Berlin : Springer Verlag
Original Publication: Berlin : Springer International, c1991-

Angiotensin II Type 1 Receptor Blockers/*administration & dosage ; Benzimidazoles/*administration & dosage ; Benzoates/*administration & dosage ; Diabetes Mellitus, Experimental/*complications ; Diabetic Cardiomyopathies/*drug therapy ; Diabetic Cardiomyopathies/*physiopathology ; Heart Ventricles/*drug effects ; Papillary Muscles/*drug effects; Animals ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Experimental/physiopathology ; Disease Models, Animal ; Heart Ventricles/physiopathology ; Humans ; Male ; Myocardial Contraction/drug effects ; Papillary Muscles/physiopathology ; Rats ; Rats, Wistar ; Streptozocin ; Telmisartan

The purpose of this study was to investigate the effects of telmisartan (5 × 10(-5) M) on the mechanical response of left ventricular papillary muscle in rats with streptozotocin-induced diabetes mellitus. We studied 32 rats; 16 were rendered diabetic by a single intravenous injection of streptozotocin (45 mg kg(-1) i.v.) and 16 formed a non-diabetic control group. Diabetic animals were divided into two groups: diabetic-telmisartan group and the diabetic-control group. Non-diabetic controls were further divided into the non-diabetic-telmisartan group and the non-diabetic-control group. We found: (1) Muscle twitch tension (P (0)) and contraction and relaxation rates were significantly lower in diabetic controls than in the other groups. (2) Telmisartan significantly increased P (0) in both diabetic and non-diabetic rats. (3) Times to peak tension and half-relaxation were significantly greater in groups DC and DT than in the non-diabetics. In conclusion, our data suggest that telmisartan attenuates diabetes-induced impairment of diabetic rat papillary muscles, and may thus be able to reduce cardiac complications in diabetes.

0 (Angiotensin II Type 1 Receptor Blockers)
0 (Benzimidazoles)
0 (Benzoates)
5W494URQ81 (Streptozocin)
U5SYW473RQ (Telmisartan)

Date Created: 20091027 Date Completed: 20110415 Latest Revision: 20181201

20240628

10.1007/s00592-009-0156-x

19855921