Effect of tocotrienols on iron-induced renal dysfunction and oxidative stress in rats.

Publisher: Taylor & Francis Group Country of Publication: United States NLM ID: 7801723 Publication Model: Print Cited Medium: Internet ISSN: 1525-6014 (Electronic) Linking ISSN: 01480545 NLM ISO Abbreviation: Drug Chem Toxicol Subsets: MEDLINE

Publication: [Philadelphia, PA] : Taylor & Francis Group
Original Publication: New York, Dekker.

Blood Urea Nitrogen*; Creatinine/*blood ; Kidney/*drug effects ; Kidney Diseases/*drug therapy ; Lipid Peroxidation/*drug effects ; Oxidative Stress/*drug effects ; Tocotrienols/*therapeutic use; Animals ; Anticarcinogenic Agents/pharmacology ; Carcinogens/toxicity ; Ferric Compounds/toxicity ; Glutathione/metabolism ; Kidney/metabolism ; Kidney Diseases/blood ; Kidney Diseases/chemically induced ; Male ; Nitrilotriacetic Acid/analogs & derivatives ; Nitrilotriacetic Acid/toxicity ; Rats ; Rats, Wistar ; Superoxide Dismutase/metabolism ; Vitamin E/pharmacology ; alpha-Tocopherol/therapeutic use

Ferric nitrilotriacetate (Fe-NTA) is a well-established nephrotoxic agent. This study was designed to investigate the modulatory effect of the subacute administration of tocotrienol-rich fraction (T3), a product from palm oil, and alpha-tocopherol (T) on Fe-NTA-induced renal injury and oxidative stress. Fe-NTA administration markedly increased blood urea nitrogen (BUN) and serum creatinine level, which was coupled with a marked lipid peroxidation, reduced activity of glutathione levels, and morphological alterations in rat kidney. Pretreatment with T3 (50 mg/kg/day) and T (50 mg/kg/day) for 7 days before Fe-NTA administration significantly reduced the serum creatinine and BUN levels, reduced lipid peroxidation in a significant manner, and restored levels of reduced glutathione and superoxide dismutase. T3 pretreatment also attenuated the serum tumor necrosis factor-alpha levels, as compared to pretreatment with T, and restored normal renal morphology. These findings suggest a strong correlation between iron-induced oxidative stress and renal dysfunction and point toward the protective effects of T3 in Fe-NTA-induced renal injury.

0 (Anticarcinogenic Agents)
0 (Carcinogens)
0 (Ferric Compounds)
0 (Tocotrienols)
1406-18-4 (Vitamin E)
AYI8EX34EU (Creatinine)
EC 1.15.1.1 (Superoxide Dismutase)
GAN16C9B8O (Glutathione)
H4N855PNZ1 (alpha-Tocopherol)
KA90006V9D (Nitrilotriacetic Acid)
Z3U5ED15B9 (ferric nitrilotriacetate)

Date Created: 20091002 Date Completed: 20100115 Latest Revision: 20190116

20221213

10.1080/01480540903130633

19793023