[Study of copper metabolism and liver damage in TX Mice-an animal model for liver disease].

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Author(s): Chen X;Chen X; Wang CH; Feng YQ; Tang QQ; Xie QY; Liang Q; Liang XL
  • Source:
    Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology [Zhonghua Gan Zang Bing Za Zhi] 2009 Sep; Vol. 17 (9), pp. 688-90.
  • Publication Type:
    English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • Language:
    Chinese
  • Additional Information
    • Source:
      Publisher: Chongqing yi ke da xue, di 2 lin chuang xue yuan Bing du xing gan yan yan jiu suo Country of Publication: China NLM ID: 9710009 Publication Model: Print Cited Medium: Print ISSN: 1007-3418 (Print) Linking ISSN: 10073418 NLM ISO Abbreviation: Zhonghua Gan Zang Bing Za Zhi Subsets: MEDLINE
    • Publication Information:
      Original Publication: Chongqing Shi : Chongqing yi ke da xue, di 2 lin chuang xue yuan Bing du xing gan yan yan jiu suo,
    • Subject Terms:
      Mice, Inbred Strains*; Copper/*metabolism ; Liver/*metabolism ; Liver Diseases/*metabolism; Animals ; Aspartate Aminotransferases/blood ; Brain/metabolism ; Ceruloplasmin/metabolism ; Disease Models, Animal ; Female ; Kidney/metabolism ; Liver/pathology ; Liver Diseases/blood ; Liver Diseases/pathology ; Male ; Mice ; Time Factors
    • Abstract:
      Objective: To provide right time points in selection of right aged animals and the normal physiological data of TX mice.
      Methods: 7-12 months old TX and DL mice were studied, each group contained 3 female and 3 male mice of TX or DL mice. The concentration of copper in the serum, dry tissues (liver, brain and kidney), together with copper biochemistry indexes were measured. The liver histopathology was observed under light microscopy and electron microscope.
      Results: Transaminase increased significantly only in 10 and 11-month- old (AST(TX10) = 218.3 U/L, AST(TX11) = 197.5 U/L, AST(DL10) = 171.5 U/L, AST(DL11) = 165.0 U/L, P(10) less than 0.001, P(11) = 0.022), but the copper concentration of liver, brain and kidney was significantly increased during 7-12 month old (the average concentration of copper, Liver(TX) = (750.0 +/- 85.5) mg/kg, Brain(TX) = (39.7 +/- 2.2)mg/kg, Kidney(TX) = (29.8 +/- 5.0) mg/kg, Liver(DL) = (11.6 +/- 1.5) mg/kg, Brain(DL) = (16.8 +/- 0.9) mg/kg, Kidney(DL) = (14.2 +/- 1.0) mg/kg, t = 21.16, 23.60, 7.47, for all these organs P less than 0.05).
      Conclusion: TX mice is a suitable model of liver disease with natural recovery, so selecting animal model of suitable time point is very important.
    • Accession Number:
      789U1901C5 (Copper)
      EC 1.16.3.1 (Ceruloplasmin)
      EC 2.6.1.1 (Aspartate Aminotransferases)
    • Publication Date:
      Date Created: 20090930 Date Completed: 20101021 Latest Revision: 20131121
    • Publication Date:
      20231215
    • Accession Number:
      19785958