Sex differences in the regulation of Kiss1/NKB neurons in juvenile mice: implications for the timing of puberty.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Author(s): Kauffman AS;Kauffman AS; Navarro VM; Kim J; Clifton DK; Steiner RA
  • Source:
    American journal of physiology. Endocrinology and metabolism [Am J Physiol Endocrinol Metab] 2009 Nov; Vol. 297 (5), pp. E1212-21. Date of Electronic Publication: 2009 Sep 15.
  • Publication Type:
    Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901226 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1555 (Electronic) Linking ISSN: 01931849 NLM ISO Abbreviation: Am J Physiol Endocrinol Metab Subsets: MEDLINE
    • Publication Information:
      Original Publication: Bethesda, MD. : American Physiological Society
    • Subject Terms:
      Kisspeptins/*biosynthesis ; Kisspeptins/*genetics ; Neurokinin B/*biosynthesis ; Neurokinin B/*genetics ; Neurons/*physiology ; Sexual Maturation/*genetics; Animals ; Arcuate Nucleus of Hypothalamus/metabolism ; Arcuate Nucleus of Hypothalamus/physiology ; Data Interpretation, Statistical ; Female ; Gene Expression Regulation/genetics ; Gonadal Steroid Hormones/physiology ; In Situ Hybridization ; Luteinizing Hormone/blood ; Male ; Mice ; Mice, Inbred C57BL ; Orchiectomy ; Ovariectomy ; RNA, Messenger/biosynthesis ; RNA, Messenger/genetics ; Sex Characteristics ; Testosterone/blood
    • Abstract:
      In mammals, puberty onset typically occurs earlier in females than in males, but the explanation for sexual differentiation in the tempo of pubertal development is unknown. Puberty in both sexes is a brain-dependent phenomenon and involves alterations in the sensitivity of neuronal circuits to gonadal steroid feedback as well as gonadal hormone-independent changes in neuronal circuitry. Kisspeptin, encoded by the Kiss1 gene, plays an essential but ill-defined role in pubertal maturation. Neurokinin B (NKB) is coexpressed with Kiss1 in the arcuate nucleus (ARC) and is also important for puberty. We tested whether sex differences in the timing of pubertal development are attributable to sexual differentiation of gonadal hormone-independent mechanisms regulating hypothalamic Kiss1/NKB gene expression. We found that, in juvenile females, gonadotropin secretion and expression of Kiss1 and NKB in the ARC increased immediately following ovariectomy, suggesting that prepubertal females have negligible gonadal hormone-independent restraint on their reproductive axis. In contrast, in similarly aged juvenile males, no changes occurred in LH levels or Kiss1 or NKB expression following castration, suggesting that gonadal hormone-independent mechanisms restrain kisspeptin/NKB-dependent activation of the male reproductive axis before puberty. Notably, adult mice of both sexes showed comparable rapid increases in Kiss1/NKB expression and LH secretion following gonadectomy, signifying that sex differences in the regulation of ARC Kiss1/NKB neurons are manifest only during peripubertal development. Our findings demonstrate that the mechanisms controlling pubertal activation of reproduction in mice are different between the sexes and suggest that gonadal hormone-independent central restraint on pubertal timing involves Kiss1/NKB neurons in the ARC.
    • References:
      Reproduction. 2005 Jun;129(6):675-83. (PMID: 15923383)
      Neuroendocrinology. 1975;18(3):242-55. (PMID: 1186963)
      Proc Natl Acad Sci U S A. 2005 Feb 8;102(6):2129-34. (PMID: 15684075)
      J Comp Neurol. 2005 Aug 29;489(3):372-86. (PMID: 16025449)
      Res Exp Med (Berl). 1975;165(1):55-9. (PMID: 237314)
      Peptides. 2009 Jan;30(1):94-102. (PMID: 18789989)
      Endocrinology. 2004 Oct;145(10):4565-74. (PMID: 15242985)
      Biol Reprod. 1977 May;16(4):527-35. (PMID: 857945)
      J Neuroendocrinol. 2004 Feb;16(2):146-53. (PMID: 14764001)
      Mol Cell Endocrinol. 2006 Jul 25;254-255:109-19. (PMID: 16723182)
      Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10972-6. (PMID: 12944565)
      J Clin Endocrinol Metab. 2005 Mar;90(3):1849-55. (PMID: 15598687)
      N Engl J Med. 2003 Oct 23;349(17):1614-27. (PMID: 14573733)
      Neuroendocrinology. 2001 Jul;74(1):12-21. (PMID: 11435754)
      Brain Res. 2004 Nov 12;1026(2):307-12. (PMID: 15488494)
      Biochem Biophys Res Commun. 2003 Dec 26;312(4):1357-63. (PMID: 14652023)
      J Neurosci. 2007 Aug 15;27(33):8826-35. (PMID: 17699664)
      J Neurosci. 2009 Sep 23;29(38):11859-66. (PMID: 19776272)
      Endocrinology. 2006 Dec;147(12):5817-25. (PMID: 16959837)
      Endocrinology. 1969 Jun;84(6):1359-64. (PMID: 5781126)
      Endocrinology. 2005 Jul;146(7):2976-84. (PMID: 15831567)
      J Physiol. 2004 Dec 1;561(Pt 2):379-86. (PMID: 15486019)
      Horm Res. 2002;57 Suppl 2:2-14. (PMID: 12065920)
      J Neurosci. 2005 Dec 7;25(49):11349-56. (PMID: 16339030)
      Mol Cell Endocrinol. 2006 Jul 25;254-255:97-102. (PMID: 16759791)
      Endocrinology. 2007 Apr;148(4):1774-83. (PMID: 17204549)
      Neuroendocrinology. 1994 Oct;60(4):337-45. (PMID: 7529897)
      Nat Genet. 2009 Mar;41(3):354-358. (PMID: 19079066)
      J Endocrinol. 1975 Aug;66(2):183-93. (PMID: 240900)
      Endocrinology. 2004 Feb;145(2):736-42. (PMID: 14592957)
      J Neuroendocrinol. 2008 Dec;20(12):1376-81. (PMID: 19094085)
      J Adolesc Health. 2002 Apr;30(4 Suppl):44-8. (PMID: 11943574)
      J Clin Endocrinol Metab. 2007 Jul;92(7):2744-50. (PMID: 17488799)
      Endocrinology. 1997 Feb;138(2):855-8. (PMID: 9003028)
      Annu Rev Physiol. 2008;70:213-38. (PMID: 17988212)
      J Reprod Dev. 2007 Apr;53(2):367-78. (PMID: 17213691)
      Endocrinology. 2004 Sep;145(9):4073-7. (PMID: 15217982)
      Endocrinology. 2009 Aug;150(8):3664-71. (PMID: 19443569)
      J Comp Neurol. 1997 Aug 4;384(3):429-42. (PMID: 9254037)
      Endocrinology. 2005 Sep;146(9):3686-92. (PMID: 15919741)
      Brain Res Mol Brain Res. 1999 Mar 20;66(1-2):200-4. (PMID: 10095095)
      Trends Neurosci. 2007 Oct;30(10):504-11. (PMID: 17904653)
      Endocrinology. 2009 Jul;150(7):3214-20. (PMID: 19299459)
      Horm Res. 2007;68 Suppl 5:75-9. (PMID: 18174715)
      Neuroscience. 2005;132(3):703-12. (PMID: 15837132)
      J Neurosci. 2006 Jun 21;26(25):6687-94. (PMID: 16793876)
      Endocrinology. 2006 Mar;147(3):1166-74. (PMID: 16373420)
      Peptides. 2009 Jan;30(1):83-93. (PMID: 18644414)
      J Clin Endocrinol Metab. 1980 Jan;50(1):163-8. (PMID: 6985614)
      J Endocrinol. 1972 Apr;53(1):47-57. (PMID: 5021263)
      Horm Behav. 2005 Aug;48(2):141-51. (PMID: 16042964)
      Endocrinology. 2007 Dec;148(12):5752-60. (PMID: 17823266)
    • Grant Information:
      K99 HD056157 United States HD NICHD NIH HHS; HD-056157 United States HD NICHD NIH HHS; R00 HD056157 United States HD NICHD NIH HHS; U54-HD-12629 United States HD NICHD NIH HHS; U54-HD-28934 United States HD NICHD NIH HHS; U54 HD012303 United States HD NICHD NIH HHS; P50 HD012303 United States HD NICHD NIH HHS; HD-049651 United States HD NICHD NIH HHS
    • Accession Number:
      0 (Gonadal Steroid Hormones)
      0 (Kiss1 protein, mouse)
      0 (Kisspeptins)
      0 (RNA, Messenger)
      3XMK78S47O (Testosterone)
      86933-75-7 (Neurokinin B)
      9002-67-9 (Luteinizing Hormone)
    • Publication Date:
      Date Created: 20090917 Date Completed: 20120313 Latest Revision: 20220321
    • Publication Date:
      20240829
    • Accession Number:
      PMC2781353
    • Accession Number:
      10.1152/ajpendo.00461.2009
    • Accession Number:
      19755669