Associated cancers in parents and offspring of polycythaemia vera and myelofibrosis patients.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Author(s): Hemminki K;Hemminki K; Sundquist J; Bermejo JL
  • Source:
    British journal of haematology [Br J Haematol] 2009 Nov; Vol. 147 (4), pp. 526-30. Date of Electronic Publication: 2009 Sep 14.
  • Publication Type:
    Journal Article; Research Support, Non-U.S. Gov't
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 0372544 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2141 (Electronic) Linking ISSN: 00071048 NLM ISO Abbreviation: Br J Haematol Subsets: MEDLINE
    • Publication Information:
      Publication: Oxford : Wiley-Blackwell
      Original Publication: Oxford : Blackwell Scientific Publications
    • Subject Terms:
      Polycythemia Vera/*genetics ; Primary Myelofibrosis/*genetics; Female ; Genetic Predisposition to Disease ; Humans ; Male ; Parents ; Polycythemia Vera/epidemiology ; Primary Myelofibrosis/epidemiology ; Registries ; Risk Assessment/methods ; Siblings ; Sweden/epidemiology
    • Abstract:
      Polycythaemia vera (PV) and primary myelofibrosis (MF) show concordant familial clustering but limited population level data are available on the aggregation of other discordant neoplasms in these families. We used the Swedish Family-Cancer Database to assess risks for VP and MF in families of cancer patients. A total of 3530 first PV and 1606 MF patients were identified, with high concordant familial risks. Several discordant familial associations were found for PV (acute myeloid leukaemia, Hodgkin disease, prostate and bladder cancers) or for MF (chronic lymphatic leukaemia, colorectal, kidney and cervical cancers) or for both (nervous system, eye and endocrine tumours).
    • Publication Date:
      Date Created: 20090917 Date Completed: 20100330 Latest Revision: 20091029
    • Publication Date:
      20240829
    • Accession Number:
      10.1111/j.1365-2141.2009.07874.x
    • Accession Number:
      19754924