Intrahepatic bile duct dilatation due to liver metastases from colorectal carcinoma.

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  • Additional Information
    • Source:
      Publisher: American Roentgen Ray Society Country of Publication: United States NLM ID: 7708173 Publication Model: Print Cited Medium: Internet ISSN: 1546-3141 (Electronic) Linking ISSN: 0361803X NLM ISO Abbreviation: AJR Am J Roentgenol Subsets: MEDLINE
    • Publication Information:
      Publication: <2004-> : Leesburg, VA : American Roentgen Ray Society
      Original Publication: Springfield, Ill., Thomas.
    • Subject Terms:
      Tomography, X-Ray Computed*; Bile Ducts, Intrahepatic/*pathology ; Carcinoma, Hepatocellular/*complications ; Carcinoma, Hepatocellular/*secondary ; Colorectal Neoplasms/*pathology ; Liver Neoplasms/*complications ; Liver Neoplasms/*secondary; Adult ; Aged ; Aged, 80 and over ; Chi-Square Distribution ; Contrast Media ; Dilatation, Pathologic/diagnostic imaging ; Dilatation, Pathologic/etiology ; Female ; Humans ; Logistic Models ; Male ; Middle Aged ; Neoplasm Staging ; Radiographic Image Interpretation, Computer-Assisted ; Retrospective Studies ; Triiodobenzoic Acids
    • Abstract:
      Objective: The objective of our study was to assess the association between colorectal liver metastases and intrahepatic bile duct dilatation and compare its frequency with the frequency of intrahepatic bile duct dilatation in other common noncolorectal metastases and hepatocellular carcinoma (HCC).
      Materials and Methods: A retrospective review of the radiology database was performed to obtain the records of patients who underwent CT for staging of histologically proven colorectal carcinoma (n = 1,000), noncolorectal carcinomas (n = 1,000), and HCC (n = 226). The CT scans of the 2,226 patients were reviewed for the presence of liver metastases and masses, the presence of intrahepatic bile duct dilatation directly related to the masses, the size of the largest lesion, and the associated caliber of the dilated intrahepatic bile duct.
      Results: Of the 297 patients with colorectal liver metastases, 49 (16.5%) had intrahepatic bile duct dilatation, whereas of the 263 patients with noncolorectal liver metastases, only eight (3%) had dilated ducts. Thirteen (5.7%) of the 226 patients with HCC had intrahepatic bile duct dilatation. Intrahepatic bile duct dilatation was present in significantly more patients with colorectal liver metastases (p < 0.05) than those with noncolorectal and HCC metastases. The mean sizes of the lesions and mean caliber of the dilated bile duct from colorectal metastases, noncolorectal metastases, and HCC were 5.3, 3.9, and 5.6 cm, respectively, and 5.1, 4.6, and 4.8 mm, respectively. Overall lesion size irrespective of diagnosis had no significant correlation with the probability of bile duct dilatation (p = 0.16; odds ratio = 1.08; 95% CI, 0.97-1.20). Lesion size also did not have a significantly different effect on the probability of dilatation for the three diagnoses (p = 0.71). The caliber of bile duct dilatation did not significantly differ among the three groups of patients by diagnosis (p = 0.70).
      Conclusion: Colorectal liver metastases have a significantly higher tendency to cause intrahepatic bile duct dilatation than noncolorectal metastases and HCC due to the characteristic features, such as cholangiocarcinoma, of intrabiliary growth. This association has important diagnostic, surgical, and prognostic implications that make it necessary to highlight this finding while communicating with clinical colleagues.
    • Accession Number:
      0 (Contrast Media)
      0 (Triiodobenzoic Acids)
      HW8W27HTXX (iodixanol)
    • Publication Date:
      Date Created: 20090822 Date Completed: 20090929 Latest Revision: 20161125
    • Publication Date:
      20231215
    • Accession Number:
      10.2214/AJR.08.2182
    • Accession Number:
      19696289