[Effect of intravenous administration of cimetidine on renal excretion of calcium, phosphates, magnesium and adenosine cyclic monophosphate].

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  • Author(s): Głuszek J;Głuszek J; Skołuda A; Pupek-Musialik D
  • Source:
    Polski tygodnik lekarski (Warsaw, Poland : 1960) [Pol Tyg Lek] 1990 Oct 1-8; Vol. 45 (40-41), pp. 817-9.
  • Publication Type:
    English Abstract; Journal Article
  • Language:
    Polish
  • Additional Information
    • Transliterated Title:
      Wpływ dozylnego podania cymetydyny na nerkowe wydalanie wapnia, fosforanów, magnezu oraz cyklicznego adenozynomonofosforanu.
    • Source:
      Publisher: Panstwowy Zaklad Wydawnictw Lekarskich Country of Publication: Poland NLM ID: 9705468 Publication Model: Print Cited Medium: Print ISSN: 0032-3756 (Print) Linking ISSN: 00323756 NLM ISO Abbreviation: Pol Tyg Lek Subsets: MEDLINE
    • Publication Information:
      Publication: Warszawa : Panstwowy Zaklad Wydawnictw Lekarskich
      Original Publication: Warszawa : Państwowy Zakład Wydawnictw Lekarskich, [1960-1996]
    • Subject Terms:
      Models, Biological*; Calcium/*urine ; Cimetidine/*administration & dosage ; Cyclic AMP/*urine ; Kidney/*metabolism ; Magnesium/*urine ; Phosphates/*urine; Adult ; Female ; Humans ; Infusions, Intravenous ; Kidney/drug effects ; Male ; Middle Aged
    • Abstract:
      An effect of cimetidine on parathyroid glands functioning in healthy subjects was evaluated. Serum calcium, phosphate, and magnesium concentrations together with renal excretion++ of these ions in healthy subjects as well as cAMP excretion++ in selected individuals were determined before and following intravenous administration of cimetidine (Altratmet Lek Ljublijana) in total dose of 500 mg (50 mg injected rapidly as a bolus following with 450 mg in an intravenous infusion during 60 minutes). No significant changes in serum calcium, phosphates, and magnesium concentrations were noted. Renal clearance of calcium and magnesium remained unchanged whereas renal phosphate excretion++ increased from 10.69 +/- 4.9 mL/min to 15.1 +/- 5.41 mL/min (p less than 0.02). Excretion++ of 3.5 cAMP increased from 2.65 +/- 2.19 nM/min to 5.16 +/- 2.0 nM/min (p less than 05). The obtained results do not exclude stimulating effect of intravenous cimetidine on parathyroid glands. Cimetidine given intravenously in the bleeding gastric or duodenal ulcers in the course of the primary hyperparathyroidism+ may decrease serum phosphate levels due to increased exretion of this ion with the urine.
    • Accession Number:
      0 (Phosphates)
      80061L1WGD (Cimetidine)
      E0399OZS9N (Cyclic AMP)
      I38ZP9992A (Magnesium)
      SY7Q814VUP (Calcium)
    • Publication Date:
      Date Created: 19901001 Date Completed: 19910716 Latest Revision: 20131121
    • Publication Date:
      20221208
    • Accession Number:
      1965742