[On human ageing and longevity--2. Internal determinants].

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  • Author(s): Brdicka R;Brdicka R
  • Source:
    Casopis lekaru ceskych [Cas Lek Cesk] 2009; Vol. 148 (7), pp. 330-4.
  • Publication Type:
    English Abstract; Journal Article; Review
  • Language:
    Czech
  • Additional Information
    • Transliterated Title:
      O lidském stárnutí a dlouhovekosti--2. Vnitrní podmínky.
    • Source:
      Publisher: Ceskoslovenska Lekarska Spolecnost Country of Publication: Czech Republic NLM ID: 0004743 Publication Model: Print Cited Medium: Print ISSN: 0008-7335 (Print) Linking ISSN: 00087335 NLM ISO Abbreviation: Cas Lek Cesk Subsets: MEDLINE
    • Publication Information:
      Original Publication: Praha : Ceskoslovenska Lekarska Spolecnost
    • Subject Terms:
      Aging/*physiology ; Longevity/*physiology; Aging/genetics ; Animals ; Humans ; Longevity/genetics
    • Abstract:
      Longevity as a result of prolonged or postponed ageing is substantially influenced by genetic determinants. Most of them were analyzed by studying different progeria syndromes and their genetic control. From this point of view the use of experimental animals, because it enables to identify genes involved in shortening or prolongation of life-span by changing experimental conditions, has been also very effective. Expression of ageing processes at cellular as well on organism level as a biological unit revealed sets of genetic pathways involved in longevity. Several theories which elicit different aspects have been constructed to explain the ageing process.
    • Number of References:
      59
    • Publication Date:
      Date Created: 20090801 Date Completed: 20090825 Latest Revision: 20090731
    • Publication Date:
      20231215
    • Accession Number:
      19642300