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Physiology and pharmacology of melatonin in relation to biological rhythms.
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- Author(s): Zawilska JB;Zawilska JB; Skene DJ; Arendt J
- Source:
Pharmacological reports : PR [Pharmacol Rep] 2009 May-Jun; Vol. 61 (3), pp. 383-410.
- Publication Type:
Journal Article; Research Support, Non-U.S. Gov't; Review
- Language:
English
- Additional Information
- Source:
Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101234999 Publication Model: Print Cited Medium: Print ISSN: 1734-1140 (Print) Linking ISSN: 17341140 NLM ISO Abbreviation: Pharmacol Rep Subsets: MEDLINE
- Publication Information:
Publication: 2020- : Cham, Switzerland : Springer International Publishing
Original Publication: Kraków, Poland : Institute of Pharmacology, Polish Academy of Sciences, c2005-
- Subject Terms:
- Abstract:
Melatonin is an evolutionarily conserved molecule that serves a time-keeping function in various species. In vertebrates, melatonin is produced predominantly by the pineal gland with a marked circadian rhythm that is governed by the central circadian pacemaker (biological clock) in the suprachiasmatic nuclei of the hypothalamus. High levels of melatonin are normally found at night, and low levels are seen during daylight hours. As a consequence, melatonin has been called the "darkness hormone". This review surveys the current state of knowledge regarding the regulation of melatonin synthesis, receptor expression, and function. In particular, it addresses the physiological, pathological, and therapeutic aspects of melatonin in humans, with an emphasis on biological rhythms.
- Number of References:
369
- Accession Number:
0 (Receptors, Melatonin)
EC 2.3.1.87 (Arylalkylamine N-Acetyltransferase)
JL5DK93RCL (Melatonin)
- Publication Date:
Date Created: 20090717 Date Completed: 20091130 Latest Revision: 20220408
- Publication Date:
20231215
- Accession Number:
10.1016/s1734-1140(09)70081-7
- Accession Number:
19605939
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