Biotechnological production of enantiopure epoxides by enzymatic kinetic resolution.

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  • Author(s): Choi WJ;Choi WJ
  • Source:
    Applied microbiology and biotechnology [Appl Microbiol Biotechnol] 2009 Aug; Vol. 84 (2), pp. 239-47. Date of Electronic Publication: 2009 Jul 10.
  • Publication Type:
    Journal Article; Research Support, Non-U.S. Gov't; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Springer International Country of Publication: Germany NLM ID: 8406612 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0614 (Electronic) Linking ISSN: 01757598 NLM ISO Abbreviation: Appl Microbiol Biotechnol Subsets: MEDLINE
    • Publication Information:
      Original Publication: Berlin ; New York : Springer International, c1984-
    • Subject Terms:
      Epoxide Hydrolases/*metabolism ; Epoxy Compounds/*metabolism; Bioreactors/microbiology ; Catalysis ; Chemistry, Pharmaceutical ; Epoxide Hydrolases/isolation & purification ; Epoxy Compounds/chemistry ; Industrial Microbiology ; Kinetics ; Stereoisomerism
    • Abstract:
      Enantiopure epoxides are high value-added synthons for the production of pharmaceuticals, agrochemicals, as well as versatile fine chemicals and have broad scope of market demand for their applications. A major challenge in conventional organic synthesis is to generate such compounds in high enantiopurity with reasonable yield. Among possible chemical and biological technologies for enantiopure epoxide preparation, enzymatic kinetic resolution has been paid much attention with respect to its high enantioselectivity. Epoxide hydrolase (EH) has shown promising characteristics for the preparation of enantiopure epoxides and vicinal diols during enantioselective hydrolysis of racemic epoxides. EH is readily available from microbial resources thus it is being employed for biohydrolysis of a variety of epoxides. Recent technical progress in EH-catalyzed enantioselective hydrolysis is summarized in terms of exploration of novel EH, its functional improvement, high throughput assay, and preparative scale resolution process.
    • Number of References:
      78
    • Accession Number:
      0 (Epoxy Compounds)
      EC 3.3.2.- (Epoxide Hydrolases)
    • Publication Date:
      Date Created: 20090711 Date Completed: 20091022 Latest Revision: 20091119
    • Publication Date:
      20240829
    • Accession Number:
      10.1007/s00253-009-2110-9
    • Accession Number:
      19590868