Characteristics of menstruation and pregnancy and the risk of lung cancer in women.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Author(s): Koushik A;Koushik A; Parent ME; Siemiatycki J
  • Source:
    International journal of cancer [Int J Cancer] 2009 Nov 15; Vol. 125 (10), pp. 2428-33.
  • Publication Type:
    Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Wiley-Liss Country of Publication: United States NLM ID: 0042124 Publication Model: Print Cited Medium: Internet ISSN: 1097-0215 (Electronic) Linking ISSN: 00207136 NLM ISO Abbreviation: Int J Cancer Subsets: MEDLINE
    • Publication Information:
      Publication: 1995- : New York, NY : Wiley-Liss
      Original Publication: 1966-1984 : Genève : International Union Against Cancer
    • Subject Terms:
      Menstruation* ; Pregnancy Complications, Neoplastic*; Lung Neoplasms/*etiology; Adenocarcinoma/epidemiology ; Adenocarcinoma/etiology ; Adult ; Aged ; Canada/epidemiology ; Carcinoma, Large Cell/epidemiology ; Carcinoma, Large Cell/etiology ; Carcinoma, Squamous Cell/epidemiology ; Carcinoma, Squamous Cell/etiology ; Case-Control Studies ; Female ; Humans ; Lung Neoplasms/epidemiology ; Male ; Middle Aged ; Ovariectomy ; Pregnancy ; Risk Factors ; Small Cell Lung Carcinoma/epidemiology ; Small Cell Lung Carcinoma/etiology
    • Abstract:
      Lung tissue, both normal and cancerous, has been found to express estrogen receptors and patterns of expression have differed between men and women, suggesting a possible role for hormone-related factors in lung carcinogenesis in women. Few epidemiological studies have examined hormone-related variables and lung cancer risk and the findings have not been consistent. We investigated the association between characteristics of menstruation and pregnancy in relation to lung cancer risk in a population-based case-control study carried out in Montreal, Canada, including 422 women with lung cancer and 577 controls. For each variable, odds ratios (OR) and 95% confidence intervals (CI) were estimated using unconditional logistic regression modeling. Associations were also examined according to level of smoking and by lung cancer histology. All statistical tests were two-sided. Most characteristics of menstruation and pregnancy were not associated with lung cancer risk. However, an increased risk was observed for women who had had a non-natural menopause, which predominantly included women who had had a bilateral oophorectomy, compared with women who had had a natural menopause (OR = 1.92, 95% CI: 1.22-3.01). An inverse association with age at menopause was suggested. These results did not vary by level of smoking and they were similar for adenocarcinomas compared with other histological types. Our results suggest that hormonal factors, related to early menopause and/or ovary removal, may play a role in the risk of lung cancer. Further studies are needed to confirm these findings, and to assess the possible contribution of hormone replacement therapy.
    • Publication Date:
      Date Created: 20090709 Date Completed: 20091105 Latest Revision: 20220310
    • Publication Date:
      20240829
    • Accession Number:
      10.1002/ijc.24560
    • Accession Number:
      19585503