[Origin and role of circulating catecholamines in the normotensive sympathectomized rat].

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  • Author(s): Lo M;Lo M; Julien C; Boomsma F; Barrès C; Sassard J
  • Source:
    Archives des maladies du coeur et des vaisseaux [Arch Mal Coeur Vaiss] 1991 Aug; Vol. 84 (8), pp. 1231-4.
  • Publication Type:
    English Abstract; Journal Article
  • Language:
    French
  • Additional Information
    • Transliterated Title:
      Origine et rôle des catécholamines circulantes chez le rat normotendu sympathectomisé.
    • Source:
      Publisher: Baillière Country of Publication: France NLM ID: 0406011 Publication Model: Print Cited Medium: Print ISSN: 0003-9683 (Print) Linking ISSN: 00039683 NLM ISO Abbreviation: Arch Mal Coeur Vaiss Subsets: MEDLINE
    • Publication Information:
      Original Publication: Paris, Baillière.
    • Subject Terms:
      Blood Pressure*/drug effects ; Sympathectomy, Chemical*; Catecholamines/*physiology; Adrenal Medulla/physiology ; Animals ; Catecholamines/biosynthesis ; Catecholamines/blood ; Guanethidine ; Male ; Phentolamine/pharmacology ; Phenylephrine/pharmacology ; Rats
    • Abstract:
      Early chronic treatment with guanethidine destroys peripheral sympathetic nerves while sparing the adrenal medulla, and does not lower blood pressure (BP) in conscious normotensive rats (Julien et al. Am J Physiol 1990; 259: H1337). Therefore, the origin and role of circulating catecholamines (CAs) in BP maintenance were examined in conscious normotensive control, sympathectomized (SNX)--daily s.c. injections of guanethidine from 1 to 13 weeks of age--and sympathectomized-adrenalectomized (SNX-A) rats by measuring i) their plasma CAs (norepinephrine, NE and epinephrine, E) and 3,4-dihydroxyphenylglycol (DHPG) by HPLC-FD, and ii) their mean BP (MBP) responses to phenylephrine and phentolamine (5 mg/kg i.v.). The doses of phenylephrine that produced similar MBP rises were 3 micrograms/kg in controls (44 +/- 4 mmHg) and 1.5 micrograms/kg in SNX (47 +/- 3 mmHg) and SNX-A (48 +/- 2 mmHg) rats. Results are as follows: [table: see text] In conclusion, in conscious normotensive SNX rats: (1) most of the circulating NE is of adrenomedullary origin and plasma DHPG derives from neuronal NE; (2) due to supersensitivity of the cardiovascular system, stimulation of alpha-adrenoreceptors by circulating CAs play a significant role in BP maintenance.
    • Accession Number:
      0 (Catecholamines)
      1WS297W6MV (Phenylephrine)
      Z468598HBV (Phentolamine)
      ZTI6C33Q2Q (Guanethidine)
    • Publication Date:
      Date Created: 19910801 Date Completed: 19911203 Latest Revision: 20131121
    • Publication Date:
      20221208
    • Accession Number:
      1953273