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Breaking a temporal barrier: signalling crosstalk regulates the initiation of border cell migration.
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- Author(s): Godt D; Tepass U
- Source:
Nature cell biology [Nat Cell Biol] 2009 May; Vol. 11 (5), pp. 536-8.
- Publication Type:
News
- Language:
English
- Additional Information
- Source:
Publisher: Macmillan Magazines Ltd Country of Publication: England NLM ID: 100890575 Publication Model: Print Cited Medium: Internet ISSN: 1476-4679 (Electronic) Linking ISSN: 14657392 NLM ISO Abbreviation: Nat Cell Biol Subsets: MEDLINE
- Publication Information:
Original Publication: London : Macmillan Magazines Ltd., [1999-
- Subject Terms:
- Abstract:
Correct timing of developmental events is crucial for generating a normal organism. During oogenesis in Drosophila melanogaster, migration of border cells occurs in a defined temporal window and requires Jak/Stat and steroid hormone signalling. The initiation of border-cell migration is now shown to be timed by Jak/Stat-mediated downregulation of the BTB domain transcriptional regulator Abrupt, which acts as a negative regulator of steroid hormone signalling.
- References:
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- Accession Number:
0 (CCAAT-Enhancer-Binding Proteins)
0 (Drosophila Proteins)
0 (Nuclear Proteins)
0 (Receptors, Steroid)
0 (STAT Transcription Factors)
0 (TAI protein, Drosophila)
0 (Transcription Factors)
0 (ab protein, Drosophila)
0 (ecdysone receptor)
148997-45-9 (slbo protein, Drosophila)
3604-87-3 (Ecdysone)
EC 2.7.10.2 (Janus Kinases)
EC 2.7.10.2 (hop protein, Drosophila)
- Publication Date:
Date Created: 20090501 Date Completed: 20090602 Latest Revision: 20211020
- Publication Date:
20240829
- Accession Number:
10.1038/ncb0509-536
- Accession Number:
19404334
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