Regulation of arterial remodeling and angiogenesis by urokinase-type plasminogen activator.

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  • Author(s): Tkachuk VA;Tkachuk VA; Plekhanova OS; Parfyonova YV
  • Source:
    Canadian journal of physiology and pharmacology [Can J Physiol Pharmacol] 2009 Apr; Vol. 87 (4), pp. 231-51.
  • Publication Type:
    Journal Article; Research Support, Non-U.S. Gov't; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Canadian Science Publishing Country of Publication: Canada NLM ID: 0372712 Publication Model: Print Cited Medium: Print ISSN: 0008-4212 (Print) Linking ISSN: 00084212 NLM ISO Abbreviation: Can J Physiol Pharmacol Subsets: MEDLINE
    • Publication Information:
      Publication: 2011- : Ottawa, ON : Canadian Science Publishing
      Original Publication: Ottawa, National Research Council of Canada.
    • Subject Terms:
      Neovascularization, Physiologic*; Arteries/*pathology ; Urokinase-Type Plasminogen Activator/*physiology; Angioplasty, Balloon, Coronary ; Animals ; Cell Movement ; Cell Proliferation ; Coronary Artery Disease/etiology ; Coronary Restenosis/etiology ; Humans ; Inflammation Mediators/physiology ; Signal Transduction ; Urokinase-Type Plasminogen Activator/chemistry ; Vasculitis/etiology
    • Abstract:
      A wide variety of disorders are associated with an imbalance in the plasminogen activator system, including inflammatory diseases, atherosclerosis, intimal hyperplasia, the response mechanism to vascular injury, and restenosis. Urokinase-type plasminogen activator (uPA) is a multifunctional protein that in addition to its fibrinolytic and matrix degradation capabilities also affects growth factor bioavailability, cytokine modulation, receptor shedding, cell migration and proliferation, phenotypic modulation, protein expression, and cascade activation of proteases, inhibitors, receptors, and modulators. uPA is the crucial protein for neointimal growth and vascular remodeling. Moreover, it was recently shown to be implicated in the stimulation of angiogenesis, which makes it a promising multipurpose therapeutic target. This review is focused on the mechanisms by which uPA can regulate arterial remodeling, angiogenesis, and cell migration and proliferation after arterial injury and the means by which it modulates gene expression in vascular cells. The role of domain specificity of urokinase in these processes is also discussed.
    • Number of References:
      241
    • Accession Number:
      0 (Inflammation Mediators)
      EC 3.4.21.73 (Urokinase-Type Plasminogen Activator)
    • Publication Date:
      Date Created: 20090417 Date Completed: 20090707 Latest Revision: 20220410
    • Publication Date:
      20221213
    • Accession Number:
      10.1139/Y08-113
    • Accession Number:
      19370078