Serum uric acid levels improve prediction of incident type 2 diabetes in individuals with impaired fasting glucose: the Rancho Bernardo Study.

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  • Author(s): Kramer CK;Kramer CK; von Mühlen D; Jassal SK; Barrett-Connor E
  • Source:
    Diabetes care [Diabetes Care] 2009 Jul; Vol. 32 (7), pp. 1272-3. Date of Electronic Publication: 2009 Apr 14.
  • Publication Type:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: American Diabetes Association Country of Publication: United States NLM ID: 7805975 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1935-5548 (Electronic) Linking ISSN: 01495992 NLM ISO Abbreviation: Diabetes Care Subsets: MEDLINE
    • Publication Information:
      Publication: Alexandria Va : American Diabetes Association
      Original Publication: New York, American Diabetes Assn.
    • Subject Terms:
      Biomarkers/*blood ; Diabetes Mellitus, Type 2/*blood ; Diabetes Mellitus, Type 2/*diagnosis ; Glucose Intolerance/*diagnosis ; Uric Acid/*blood; Aged ; Blood Glucose/analysis ; Blood Glucose/metabolism ; Diabetes Mellitus, Type 2/epidemiology ; Fasting ; Female ; Glomerular Filtration Rate ; Glucose Intolerance/blood ; Humans ; Male ; Middle Aged ; Sensitivity and Specificity
    • Abstract:
      Objective: To determine whether serum uric acid predicts incident type 2 diabetes by glucose tolerance status in older community-dwelling adults.
      Research Design and Methods: Participants without diabetes at baseline were evaluated for incident type 2 diabetes 13 years later. Baseline glucose tolerance status was defined as normoglycemia, impaired fasting glucose, and impaired postchallenge glucose tolerance.
      Results: A total of 566 participants were included (mean age 63.3 +/- 8.6 years; 41% men). Regression models adjusted for age, sex, BMI, diuretic use, and estimated glomerular filtration rate showed that for each 1 mg/dl increment in uric acid levels, incident type 2 diabetes risk increased by approximately 60%. When analyses were stratified by glucose status, uric acid levels independently predicted incident type 2 diabetes among participants who had impaired fasting glucose (odds ratio 1.75, 95% CI 1.1-2.9, P = 0.02).
      Conclusions: Uric acid may be a useful predictor of type 2 diabetes in older adults with impaired fasting glucose.
    • Comments:
      Comment in: Diabetes Care. 2009 Oct;32(10):e125; author reply e126. (PMID: 19793999)
    • References:
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    • Grant Information:
      R01 DK031801 United States DK NIDDK NIH HHS; R37 AG007181 United States AG NIA NIH HHS; R01 AG028507 United States AG NIA NIH HHS; R01 AG007181 United States AG NIA NIH HHS; AG07181 United States AG NIA NIH HHS
    • Accession Number:
      0 (Biomarkers)
      0 (Blood Glucose)
      268B43MJ25 (Uric Acid)
    • Publication Date:
      Date Created: 20090416 Date Completed: 20090928 Latest Revision: 20220409
    • Publication Date:
      20240628
    • Accession Number:
      PMC2699705
    • Accession Number:
      10.2337/dc09-0275
    • Accession Number:
      19366963