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Serum uric acid levels improve prediction of incident type 2 diabetes in individuals with impaired fasting glucose: the Rancho Bernardo Study.
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- Author(s): Kramer CK;Kramer CK; von Mühlen D; Jassal SK; Barrett-Connor E
- Source:
Diabetes care [Diabetes Care] 2009 Jul; Vol. 32 (7), pp. 1272-3. Date of Electronic Publication: 2009 Apr 14.- Publication Type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't- Language:
English - Source:
- Additional Information
- Source: Publisher: American Diabetes Association Country of Publication: United States NLM ID: 7805975 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1935-5548 (Electronic) Linking ISSN: 01495992 NLM ISO Abbreviation: Diabetes Care Subsets: MEDLINE
- Publication Information: Publication: Alexandria Va : American Diabetes Association
Original Publication: New York, American Diabetes Assn. - Subject Terms: Biomarkers/*blood ; Diabetes Mellitus, Type 2/*blood ; Diabetes Mellitus, Type 2/*diagnosis ; Glucose Intolerance/*diagnosis ; Uric Acid/*blood; Aged ; Blood Glucose/analysis ; Blood Glucose/metabolism ; Diabetes Mellitus, Type 2/epidemiology ; Fasting ; Female ; Glomerular Filtration Rate ; Glucose Intolerance/blood ; Humans ; Male ; Middle Aged ; Sensitivity and Specificity
- Abstract: Objective: To determine whether serum uric acid predicts incident type 2 diabetes by glucose tolerance status in older community-dwelling adults.
Research Design and Methods: Participants without diabetes at baseline were evaluated for incident type 2 diabetes 13 years later. Baseline glucose tolerance status was defined as normoglycemia, impaired fasting glucose, and impaired postchallenge glucose tolerance.
Results: A total of 566 participants were included (mean age 63.3 +/- 8.6 years; 41% men). Regression models adjusted for age, sex, BMI, diuretic use, and estimated glomerular filtration rate showed that for each 1 mg/dl increment in uric acid levels, incident type 2 diabetes risk increased by approximately 60%. When analyses were stratified by glucose status, uric acid levels independently predicted incident type 2 diabetes among participants who had impaired fasting glucose (odds ratio 1.75, 95% CI 1.1-2.9, P = 0.02).
Conclusions: Uric acid may be a useful predictor of type 2 diabetes in older adults with impaired fasting glucose. - Comments: Comment in: Diabetes Care. 2009 Oct;32(10):e125; author reply e126. (PMID: 19793999)
- References: Diabetes Care. 2009 Jan;32 Suppl 1:S13-61. (PMID: 19118286)
Ann Intern Med. 1999 Mar 16;130(6):461-70. (PMID: 10075613)
Diabetes Care. 2006 Jun;29(6):1263-8. (PMID: 16732006)
Diabetes Care. 2001 Nov;24(11):1936-40. (PMID: 11679460)
Clin Chem. 2008 Feb;54(2):310-6. (PMID: 18089655)
Diabetes Care. 2008 Feb;31(2):361-2. (PMID: 17977935)
Diabetes Care. 2000 Sep;23(9):1278-83. (PMID: 10977060)
Diabetes Care. 2009 Jan;32(1):141-6. (PMID: 18852333)
Diabetes Nutr Metab. 1999 Aug;12(4):286-91. (PMID: 10782755)
Diabetologia. 1987 Sep;30(9):713-8. (PMID: 3322912) - Grant Information: R01 DK031801 United States DK NIDDK NIH HHS; R37 AG007181 United States AG NIA NIH HHS; R01 AG028507 United States AG NIA NIH HHS; R01 AG007181 United States AG NIA NIH HHS; AG07181 United States AG NIA NIH HHS
- Accession Number: 0 (Biomarkers)
0 (Blood Glucose)
268B43MJ25 (Uric Acid) - Publication Date: Date Created: 20090416 Date Completed: 20090928 Latest Revision: 20220409
- Publication Date: 20240628
- Accession Number: PMC2699705
- Accession Number: 10.2337/dc09-0275
- Accession Number: 19366963
- Source:
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