[Study of antibodies to motor end-plate in ocular myasthenia gravis].

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  • Additional Information
    • Source:
      Publisher: Nihon Shinkei Gakkai Country of Publication: Japan NLM ID: 0417466 Publication Model: Print Cited Medium: Print ISSN: 0009-918X (Print) Linking ISSN: 0009918X NLM ISO Abbreviation: Rinsho Shinkeigaku Subsets: MEDLINE
    • Publication Information:
      Publication: April 1963-: Tōkyō : Nihon Shinkei Gakkai
      Original Publication: Tōkyō : Nihon Rinshō Shinkei Gakkai, 1960-
    • Subject Terms:
      Oculomotor Muscles*; Autoantibodies/*analysis ; Immunoglobulin G/*analysis ; Motor Endplate/*immunology ; Myasthenia Gravis/*immunology; Adolescent ; Adult ; Aged ; Child ; Female ; Humans ; Male ; Middle Aged ; Receptors, Cholinergic/immunology
    • Abstract:
      This study was undertaken to investigate whether serum obtained from ocular MG with undetectable antibodies contains antibodies which bind to normal motor end-plates immunohistochemically. Nineteen patients with ocular MG were studied. Anti-AChR antibodies in serum were assayed by an immunoprecipitation method using human junctional AChR as the antigen. Anti-AChR antibodies in serum which bind to the junctional AChR at the motor end-plates were detected immunohistochemically by incubating the muscle with each serum. Bound IgG was detected by peroxidase labeled protein A (P-PA). IgG deposit at the own limb muscle motor end-plates (biceps brachii) was also detected by P-PA. Anti-AChR antibodies in serum were positive in 9 out of 19 patients and IgG antibodies bound to the junctional AChR were demonstrated in 16 of 19 patients. IgG bound to own end-plates was observed in 13 of 14 patients studied. In 2 patients IgG was detected at the own end-plates, but not at the not-self end-plates. These findings indicate that detection of IgG at the limb muscle end-plates serves for the diagnosis of ocular MG with undetectable antibodies in serum and anti-AChR antibodies in some patients may react exclusively with the autologous AChR.
    • Accession Number:
      0 (Autoantibodies)
      0 (Immunoglobulin G)
      0 (Receptors, Cholinergic)
    • Publication Date:
      Date Created: 19910501 Date Completed: 19911218 Latest Revision: 20061115
    • Publication Date:
      20231215
    • Accession Number:
      1934762