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Experimental infection of Richardson's ground squirrels (Spermophilus richardsonii) with attenuated and virulent strains of Brucella abortus.
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- Author(s): Nol P;Nol P; Olsen SC; Rhyan JC
- Source:
Journal of wildlife diseases [J Wildl Dis] 2009 Jan; Vol. 45 (1), pp. 189-95.- Publication Type:
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.- Language:
English - Source:
- Additional Information
- Source: Publisher: Wildlife Disease Association Country of Publication: United States NLM ID: 0244160 Publication Model: Print Cited Medium: Print ISSN: 0090-3558 (Print) Linking ISSN: 00903558 NLM ISO Abbreviation: J Wildl Dis Subsets: MEDLINE
- Publication Information: Publication: Lawrence, KS : Wildlife Disease Association
Original Publication: Ames, Iowa, Wildlife Disease Assn. - Subject Terms: Brucella Vaccine/*administration & dosage ; Brucella abortus/*pathogenicity ; Brucellosis/*veterinary ; Rodent Diseases/*microbiology ; Sciuridae/*microbiology; Administration, Oral ; Animals ; Animals, Wild/microbiology ; Brucellosis/immunology ; Brucellosis/microbiology ; Brucellosis/prevention & control ; Colony Count, Microbial/veterinary ; Female ; Male ; Rodent Diseases/immunology ; Rodent Diseases/prevention & control ; Safety ; Species Specificity ; Treatment Outcome ; Virulence
- Abstract: A previous investigation of the safety of Brucella abortus strain RB51 (sRB51) in various nontarget species suggested that Richardson's ground squirrels (Spermophilus richardsonii) may develop persistent infections when orally inoculated with the vaccine. In the present study, sRB51, B. abortus strain 19 (s19), and virulent B. abortus strain 9941 (s9941) were administered orally to Richardson's ground squirrels to further characterize B. abortus infection in this species. Six groups of nongravid ground squirrels were orally inoculated with 6 x 10(8) colony forming units (cfu) sRB51 (n = 10), 2.5 x 10(4) cfu s19 (n = 10), 2.5 x 10(7) cfu s19 (n = 6), 1.3 x 10(6) cfu s9941 (n = 5), 2.1 x 10(8) cfu s9941 (n = 5), or vaccine diluent (control; n = 4). One of five animals in the lower-dose s19 group and two of three animals in the higher-dose s19 group showed persistence of bacteria in various tissues at 14 wk postinoculation (PI). At 18 wk PI, one of five animals in the sRB51 group and one of five animals in the high-dose s9941 group were culture positive. Although we did detect some persistence of B. abortus strains at 18 wk, we found no evidence of pathology caused by B. abortus strains in nonpregnant Richardson's ground squirrels based on clinical signs, gross lesions, and microscopic lesions.
- Accession Number: 0 (Brucella Vaccine)
- Publication Date: Date Created: 20090211 Date Completed: 20090427 Latest Revision: 20090210
- Publication Date: 20221213
- Accession Number: 10.7589/0090-3558-45.1.189
- Accession Number: 19204348
- Source:
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