Cortical somatosensory evoked potentials. II. Effects of excision of somatosensory or motor cortex in humans and monkeys.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Author(s): Allison T;Allison T; Wood CC; McCarthy G; Spencer DD
  • Source:
    Journal of neurophysiology [J Neurophysiol] 1991 Jul; Vol. 66 (1), pp. 64-82.
  • Publication Type:
    Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: American Physiological Society Country of Publication: United States NLM ID: 0375404 Publication Model: Print Cited Medium: Print ISSN: 0022-3077 (Print) Linking ISSN: 00223077 NLM ISO Abbreviation: J Neurophysiol Subsets: MEDLINE
    • Publication Information:
      Publication: Bethesda Md : American Physiological Society
      Original Publication: Washington [etc.]
    • Subject Terms:
      Evoked Potentials, Somatosensory*; Cerebral Cortex/*physiology ; Motor Cortex/*physiology ; Somatosensory Cortex/*physiology; Adolescent ; Animals ; Brain Mapping ; Denervation ; Female ; Humans ; Macaca fascicularis ; Male ; Middle Aged ; Motor Cortex/surgery ; Myoclonus/physiopathology ; Myoclonus/surgery ; Somatosensory Cortex/surgery
    • Abstract:
      1. To clarify the generators of human short-latency somatosensory evoked potentials (SEPs) thought to arise in sensorimotor cortex, we studied the effects on SEPs of surgical excision of somatosensory or motor cortex in humans and monkeys. 2. Normal median nerve SEPs (P20-N30, N20-P30, and P25-N35) were recorded from the cortical surface of a patient (G13) undergoing a cortical excision for relief of focal seizures. All SEPs were abolished both acutely and chronically after excision of the hand area of somatosensory cortex. Similarly, excision of the hand area of somatosensory cortex abolished corresponding SEPs (P10-N20, N10-P20, and P12-N25) in monkeys. Excision of the crown of monkey somatosensory cortex abolished P12-N25 while leaving P10-N20 and N10-P20 relatively unaffected. 3. After excision of the hand area of motor cortex, all SEPs were present when recorded from the cortical surface of a patient (W1) undergoing a cortical excision for relief of focal seizures. Similarly, all SEPs were present in monkeys after excision of the hand area of motor cortex. 4. Although all SEPs were present after excision of motor cortex in monkeys, variable changes were observed in SEPs after the excisions. However, these changes were not larger than the changes observed after excision of parietal cortex posterior to somatosensory cortex. We concluded that the changes were not specific to motor cortex excision. 5. These results support two major conclusions. 1) Median nerve SEPs recorded from sensorimotor cortex are produced by generators in two adjacent regions of somatosensory cortex: a tangentially oriented generator in area 3b, which produces P20-N30 (human) and P10-N20 (monkey) [recorded anterior to the central sulcus (CS)] and N20-P30 (human) and N10-P20 (monkey) posterior to the CS; and a radially oriented generator in area 1, which produces P25-N35 (human) and P12-N25 (monkey) recorded from the postcentral gyrus near the CS. 2) Motor cortex makes little or no contribution to these potentials.
    • Grant Information:
      MH-05286 United States MH NIMH NIH HHS
    • Publication Date:
      Date Created: 19910701 Date Completed: 19911106 Latest Revision: 20171213
    • Publication Date:
      20221213
    • Accession Number:
      10.1152/jn.1991.66.1.64
    • Accession Number:
      1919677