Activity of pontine neurons during sleep and cataplexy in hypocretin knock-out mice.

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  • Author(s): Thankachan S;Thankachan S; Kaur S; Shiromani PJ
  • Source:
    The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2009 Feb 04; Vol. 29 (5), pp. 1580-5.
  • Publication Type:
    Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Society for Neuroscience Country of Publication: United States NLM ID: 8102140 Publication Model: Print Cited Medium: Internet ISSN: 1529-2401 (Electronic) Linking ISSN: 02706474 NLM ISO Abbreviation: J Neurosci Subsets: MEDLINE
    • Publication Information:
      Publication: Washington, DC : Society for Neuroscience
      Original Publication: [Baltimore, Md.] : The Society, c1981-
    • Subject Terms:
      Cataplexy/*metabolism ; Intracellular Signaling Peptides and Proteins/*deficiency ; Intracellular Signaling Peptides and Proteins/*genetics ; Neurons/*physiology ; Neuropeptides/*deficiency ; Neuropeptides/*genetics ; Pons/*physiology ; Sleep/*genetics; Animals ; Cataplexy/genetics ; Electroencephalography/methods ; Mice ; Mice, Knockout ; Orexins ; Pons/cytology ; Sleep/physiology ; Sleep, REM/genetics ; Sleep, REM/physiology
    • Abstract:
      Narcolepsy is a human sleep disorder resulting from the loss of neurons containing the neuropeptide orexin, also known as hypocretin. Cataplexy, which is a sudden loss of muscle tone during waking, is an important diagnostic symptom of narcolepsy. In humans and canines with narcolepsy, cataplexy is considered to be a separate and distinct behavioral state. However, in the mouse model of the disease this issue is not resolved. The present study monitored the activity of forty four neurons in the rostral pons in hypocretin knock-out mice. Majority of the neurons were active during wake and REM sleep, while four neurons were selectively active during REM sleep. All of these neurons were less active during cataplexy compared with REM sleep. Thus, although cataplexy and REM sleep share many common features, including the muscle atonia, cataplexy is a distinct state in mice.
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    • Grant Information:
      R01 NS052287-04 United States NS NINDS NIH HHS; R01 NS030140-15 United States NS NINDS NIH HHS; R01 NS052287 United States NS NINDS NIH HHS; R01 NS030140 United States NS NINDS NIH HHS; NS030140 United States NS NINDS NIH HHS; NS052287 United States NS NINDS NIH HHS; R01 NS052287-03 United States NS NINDS NIH HHS
    • Accession Number:
      0 (Intracellular Signaling Peptides and Proteins)
      0 (Neuropeptides)
      0 (Orexins)
    • Publication Date:
      Date Created: 20090206 Date Completed: 20090224 Latest Revision: 20211020
    • Publication Date:
      20240829
    • Accession Number:
      PMC2649763
    • Accession Number:
      10.1523/JNEUROSCI.5151-08.2009
    • Accession Number:
      19193905