[Biochemical and morphological manifestations of endothelial dysfunction of endocardium and myocardial vessels during emotional stress in combination with hypercholesterolemia].

Publisher: Naukova Dumka Country of Publication: Ukraine NLM ID: 9601541 Publication Model: Print Cited Medium: Print ISSN: 2522-9028 (Print) Linking ISSN: 25229028 NLM ISO Abbreviation: Fiziol Zh (1994) Subsets: MEDLINE

Publication: Kyiv : Naukova Dumka
Original Publication: Kyïv : Nauk. dumka, 1994-

Coronary Vessels*/metabolism ; Coronary Vessels*/ultrastructure ; Endocardium*/metabolism ; Endocardium*/ultrastructure ; Endothelium, Vascular*/metabolism ; Endothelium, Vascular*/ultrastructure ; Hypercholesterolemia*/complications ; Hypercholesterolemia*/metabolism ; Hypercholesterolemia*/pathology ; Lipid Metabolism* ; Stress, Psychological*/complications ; Stress, Psychological*/metabolism ; Stress, Psychological*/pathology; Animals ; Chromatography, Thin Layer ; Disease Models, Animal ; Endothelial Cells/metabolism ; Endothelial Cells/ultrastructure ; Lipids/blood ; Male ; Microscopy, Electron ; Myocardium/metabolism ; Myocardium/ultrastructure ; Rats

In experiments with white rats the influence of emotional and pain stress in combination with alimentary hypercholesterolemia on lipid content of membraneous structures of endotheliocytes of endocardium and microvessels of myocardium and their morphological manifestations has been studied. Combination of these etiological factors is followed by accumulation of free cholesterol and free fatty acids within the cells. This results in damage of single endotheliocytes, the most extreme manifestation of which is formation of endothelial bodies (cytoplasts) with development of microclasmatosis and desquamation of these cells.

0 (Lipids)

Date Created: 20081209 Date Completed: 20090105 Latest Revision: 20081208

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