[Mechanisms causing chronic renal injury in kidney disease and their possible reversibility].

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  • Author(s): Bussolati B;Bussolati B; Collino F; Camussi G
  • Source:
    Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia [G Ital Nefrol] 2008 Nov-Dec; Vol. 25 Suppl 44, pp. S3-S10.
  • Publication Type:
    English Abstract; Journal Article
  • Language:
    Italian
  • Additional Information
    • Transliterated Title:
      I meccanismi del danno cronico renale nelle nefropatie e la loro possibile reversibilita.
    • Source:
      Publisher: Società Italiana di Nefrologia Country of Publication: Italy NLM ID: 9426434 Publication Model: Print Cited Medium: Print ISSN: 0393-5590 (Print) Linking ISSN: 03935590 NLM ISO Abbreviation: G Ital Nefrol Subsets: MEDLINE
    • Publication Information:
      Publication: <2013- >: Rome : Società Italiana di Nefrologia.
      Original Publication: Milano : Wichtig editore
    • Subject Terms:
      Hematopoietic Stem Cell Transplantation*; Kidney/*injuries ; Kidney Diseases/*physiopathology ; Kidney Diseases/*surgery; Cell Differentiation ; Cell Proliferation ; Disease Progression ; Epithelial Cells/metabolism ; Humans ; Italy ; Kidney Diseases/pathology ; Kidney Glomerulus/pathology ; Receptor, Angiotensin, Type 2/deficiency ; Regeneration ; Treatment Outcome
    • Abstract:
      Much study has been dedicated to the understanding of the mechanisms leading to the progression of renal injury and to the development of strategies to limit this progression or possibly induce tissue regeneration. Among several identified mechanisms, the role of angiotensin II is widely recognized. Moreover, the progression of glomerular damage is characterized by capillary loss, reduction of the proliferative response, and production of antiangiogenic factors. Several lines of evidence support the potential effect of therapeutic startegies aimed at interfering with angiotensin II or stimulating angiogenesis in order to reduce the progression of renal injury. Recent work has underlined the potential of strategies involving the use of stem cells. Different populations of stem cells have been identified in the adult kidney. During renal injury, stem cells derived from the bone marrow that migrate through the circulation to the kidney may contribute to tissue repair. The regenerative potential of stem cells could be exploited by administration of ex vivo expanded stem cell populations or by the development of techniques to expand and differentiate local stem cells.
    • Accession Number:
      0 (Receptor, Angiotensin, Type 2)
    • Publication Date:
      Date Created: 20081217 Date Completed: 20100305 Latest Revision: 20081202
    • Publication Date:
      20231215
    • Accession Number:
      19048579