The globus pallidus sends reward-related signals to the lateral habenula.

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  • Author(s): Hong S;Hong S; Hikosaka O
  • Source:
    Neuron [Neuron] 2008 Nov 26; Vol. 60 (4), pp. 720-9.
  • Publication Type:
    Journal Article; Research Support, N.I.H., Intramural
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Cell Press Country of Publication: United States NLM ID: 8809320 Publication Model: Print Cited Medium: Internet ISSN: 1097-4199 (Electronic) Linking ISSN: 08966273 NLM ISO Abbreviation: Neuron Subsets: MEDLINE
    • Publication Information:
      Original Publication: [Cambridge, Mass. : Cell Press, c1988-
    • Subject Terms:
      Reward*; Action Potentials/*physiology ; Globus Pallidus/*physiology ; Habenula/*physiology ; Neurons/*physiology; Animals ; Bias ; Biogenic Amines/metabolism ; Emotions/physiology ; Globus Pallidus/anatomy & histology ; Habenula/anatomy & histology ; Limbic System/anatomy & histology ; Limbic System/physiology ; Macaca mulatta ; Neural Pathways/anatomy & histology ; Neural Pathways/physiology ; Neuropsychological Tests ; Reinforcement, Psychology ; Saccades/physiology
    • Abstract:
      As a major output station of the basal ganglia, the globus pallidus internal segment (GPi) projects to the thalamus and brainstem nuclei thereby controlling motor behavior. A less well known fact is that the GPi also projects to the lateral habenula (LHb) which is often associated with the limbic system. Using the monkey performing a saccade task with positionally biased reward outcomes, we found that antidromically identified LHb-projecting neurons were distributed mainly in the dorsal and ventral borders of the GPi and that their activity was strongly modulated by expected reward outcomes. A majority of them were excited by the no-reward-predicting target and inhibited by the reward-predicting target. These reward-dependent modulations were similar to those in LHb neurons but started earlier than those in LHb neurons. These results suggest that GPi may initiate reward-related signals through its effects on the LHb, which then influences the dopaminergic and serotonergic systems.
    • Comments:
      Comment in: Neuron. 2008 Nov 26;60(4):530-1. (PMID: 19038211)
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    • Grant Information:
      Z01 EY000415-05 United States ImNIH Intramural NIH HHS
    • Accession Number:
      0 (Biogenic Amines)
    • Publication Date:
      Date Created: 20081129 Date Completed: 20090116 Latest Revision: 20220408
    • Publication Date:
      20231215
    • Accession Number:
      PMC2638585
    • Accession Number:
      10.1016/j.neuron.2008.09.035
    • Accession Number:
      19038227