Structural and functional analysis of fatty acid-binding proteins.

Publisher: Elsevier Country of Publication: United States NLM ID: 0376606 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0022-2275 (Print) Linking ISSN: 00222275 NLM ISO Abbreviation: J Lipid Res Subsets: MEDLINE

Publication: 2021- : [New York] : Elsevier
Original Publication: Memphis, Lipid Research, inc.

Fatty Acid-Binding Proteins/*chemistry ; Fatty Acid-Binding Proteins/*metabolism; Adipocytes/metabolism ; Animals ; Fatty Acid-Binding Proteins/classification ; Fatty Acid-Binding Proteins/genetics ; Humans ; Intestinal Mucosa/metabolism ; Keratinocytes/metabolism ; Liver/metabolism ; Organ Specificity

The mammalian FA-binding proteins (FABPs) bind long-chain FA with high affinity. The large number of FABP types is suggestive of distinct functions in specific tissues. Multiple experimental approaches have shown that individual FABPs possess both unique and overlapping functions, some of which are based on specific elements in the protein structure. Although FA binding affinities for all FABPs tend to correlate directly with FA hydrophobicity, structure-function studies indicate that subtle three-dimensional changes that occur upon ligand binding may promote specific protein-protein or protein-membrane interactions that ultimately determine the function of each FABP. The conformational changes are focused in the FABP helical/portal domain, a region that was identified by in vitro studies to be vital for the FA transport properties of the FABPs. Thus, the FABPs modulate intracellular lipid homeostasis by regulating FA transport in the nuclear and extra-nuclear compartments of the cell; in so doing, they also impact systemic energy homeostasis.

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Cell. 2008 Sep 19;134(6):933-44. (PMID: 18805087)
Biochemistry. 2001 May 29;40(21):6475-85. (PMID: 11371211)
J Mol Biol. 2007 Oct 5;372(5):1246-60. (PMID: 17761196)
Annu Rev Nutr. 2008;28:73-95. (PMID: 18435590)
Biochemistry. 2003 Jun 24;42(24):7339-47. (PMID: 12809489)
Hepatology. 2006 Nov;44(5):1191-205. (PMID: 17058218)
J Biol Chem. 1994 Sep 30;269(39):23918-30. (PMID: 7929039)
Biochim Biophys Acta. 2000 Jun 26;1486(1):28-44. (PMID: 10856711)
J Invest Dermatol. 2003 Jul;121(1):132-41. (PMID: 12839573)
J Biochem. 2000 Sep;128(3):355-61. (PMID: 10965032)
Genomics. 2008 Dec;92(6):436-45. (PMID: 18786628)
Adv Protein Chem. 1994;45:89-151. (PMID: 8154375)
Nat Rev Drug Discov. 2008 Jun;7(6):489-503. (PMID: 18511927)
Mol Cell Biochem. 1999 Feb;192(1-2):9-16. (PMID: 10331654)
FASEB J. 2000 Oct;14(13):2040-6. (PMID: 11023988)
Biochemistry. 2002 Apr 30;41(17):5453-61. (PMID: 11969406)
Biochemistry. 2007 Nov 6;46(44):12543-56. (PMID: 17927211)
Biochemistry. 2007 Jun 12;46(23):6744-52. (PMID: 17516629)
J Clin Invest. 1995 Mar;95(3):1281-7. (PMID: 7883976)
J Biol Chem. 2003 Jun 13;278(24):21429-38. (PMID: 12670956)
J Biol Chem. 2007 Nov 2;282(44):32424-32. (PMID: 17785468)
Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2323-8. (PMID: 11226238)
Proteins. 1998 Dec 1;33(4):577-89. (PMID: 9849941)
J Biol Chem. 2008 Nov 28;283(48):33536-43. (PMID: 18820256)
Cell. 2007 May 18;129(4):723-33. (PMID: 17512406)
Biochemistry. 2000 Jun 20;39(24):7197-204. (PMID: 10852718)
Eur J Neurosci. 2006 Jul;24(1):175-87. (PMID: 16882015)
J Biol Chem. 2000 Sep 1;275(35):27045-54. (PMID: 10854433)
J Cell Biol. 1994 Nov;127(4):1097-109. (PMID: 7962070)
Mol Cell Biochem. 1999 Feb;192(1-2):77-85. (PMID: 10331661)
J Biol Chem. 2007 Jun 22;282(25):17974-17984. (PMID: 17449472)
Clin Biochem. 1998 Nov;31(8):609-12. (PMID: 9876891)
Proc Natl Acad Sci U S A. 2008 May 27;105(21):7546-51. (PMID: 18495924)
Oncogene. 2000 May 11;19(20):2455-60. (PMID: 10828888)
J Biol Chem. 2002 Dec 27;277(52):50693-702. (PMID: 12386159)
Am J Physiol Gastrointest Liver Physiol. 2008 Jan;294(1):G307-14. (PMID: 18032478)

R01 DK038389 United States DK NIDDK NIH HHS

0 (Fatty Acid-Binding Proteins)

Date Created: 20081120 Date Completed: 20090605 Latest Revision: 20211020

20231215

PMC2674722

10.1194/jlr.R800084-JLR200

19017610