[Alcohol dehydrogenase and aldehyde dehydrogenase in malignant diseases--Part II].

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  • Author(s): Orywal K;Orywal K; Jelski W; Szmitkowski M
  • Source:
    Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego [Pol Merkur Lekarski] 2008 Aug; Vol. 25 (146), pp. 184-7.
  • Publication Type:
    English Abstract; Journal Article; Review
  • Language:
    Polish
  • Additional Information
    • Transliterated Title:
      Dehydrogenaza alkoholowa i aldehydowa w chorobach nowotworowych--Cześć II.
    • Source:
      Publisher: Aluna Publishing Country of Publication: Poland NLM ID: 9705469 Publication Model: Print Cited Medium: Print ISSN: 1426-9686 (Print) Linking ISSN: 14269686 NLM ISO Abbreviation: Pol Merkur Lekarski Subsets: MEDLINE
    • Publication Information:
      Publication: 2023- : Konstancin-Jeziorna, Poland : Aluna Publishing
      Original Publication: Warszawa : MEDPRESS, [1996-
    • Subject Terms:
      Alcohol Dehydrogenase/*blood ; Aldehyde Dehydrogenase/*blood ; Breast Neoplasms/*enzymology ; Digestive System Neoplasms/*enzymology; Alcohol Drinking/epidemiology ; Alcoholism/epidemiology ; Breast Neoplasms/epidemiology ; Causality ; Comorbidity ; Digestive System Neoplasms/epidemiology ; Humans
    • Abstract:
      Heavy alcohol consumption is associated with increased risk of cancers including digestive tract, liver, pancreas, colorectum and breast. Direct correlations between alcohol consumption and development of cancer are still unknown. The differences in activities of ADH and ALDH between cancer tissues and normal mucosa might be a factor for metabolic changes and disturbances in low- mature cancer cells, might be a reason for the high level of acetaldehyde and intensifying carcinogenesis. Moreover releasing ADH and ALDH from cancer cells can cause increase of these enzymes activities in the sera of patients with cancer.
    • Number of References:
      25
    • Accession Number:
      EC 1.1.1.1 (Alcohol Dehydrogenase)
      EC 1.2.1.3 (Aldehyde Dehydrogenase)
    • Publication Date:
      Date Created: 20081024 Date Completed: 20081113 Latest Revision: 20081023
    • Publication Date:
      20231215
    • Accession Number:
      18942344