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Wando Mount Pleasant Library
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The wound repair response controls outcome to cutaneous leishmaniasis. (English)
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- Author(s): Sakthianandeswaren, Anuratha; Elso, Colleen M.; Simpson, Ken; Curtis, Joan M.; Kumar, Beena; Speed, Terence P.; Handman, Emanuela; Foote, Simon J.
- Source:
Proceedings of the National Academy of Sciences of the United States of America; 10/25/2005, Vol. 102 Issue 43, p15551-15556, 6p- Subject Terms:
- Source:
- Additional Information
- Abstract: Chronic microbial infections are associated with fibrotic and inflammatory reactions known as granulomas showing similarities to wound-healing and tissue repair processes. We have previously mapped three leishmaniasis susceptibility loci, designated Imr1, -2, and -3, which exert their effect independently of I cell immune responses. Here, we show that the wound repair response is critically important for the rapid cure in murine cutaneous leishmaniasis caused by Leishmania major. Mice congenic for leishmaniasis resistance loci, which cured their lesions more rapidly than their susceptible parents, also expressed differentially genes involved in tissue repair, laid down more ordered collagen fibers, and healed punch biopsy wounds more rapidly. Fibroblast monolayers from these mice repaired in vitro wounds faster, and this process was accelerated by supernatants from infected macrophages. Because these effects are independent of T cell-mediated immunity, we conclude that the rate of wound healing is likely to be an important component of innate immunity involved in resistance to cutaneous leishmaniasis. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Proceedings of the National Academy of Sciences of the United States of America is the property of National Academy of Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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