Multivariate analysis of factors associated with renal dysfunction in patients with obstructive jaundice.

The article evaluates the role of hormones in the pathogenesis of renal dysfunction in patients with biliary tract obstruction. The extracellular body water compartment, plasma level of aldosterone, renin, atrial natriuretic peptide, vasopressin, nitric oxide, endothelin (ET) 1 and prostaglandin E2 (PGE2), urinary nitric oxide and PGE2, serum albumin and renal function were analyzed. The results of the study are discussed. The study suggests that renal dysfunction in patients with obstructive jaundice was associated with the degree of biliary obstruction, age of the patient and reduced urinary sodium excretion.