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Biology and evolution of the endogenous koala retrovirus.
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- Author(s): Tarlinton R;Tarlinton R; Meers J; Young P
- Source:
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2008 Nov; Vol. 65 (21), pp. 3413-21.
- Publication Type:
Journal Article; Research Support, Non-U.S. Gov't; Review
- Language:
English
- Additional Information
- Source:
Publisher: Springer Country of Publication: Switzerland NLM ID: 9705402 Publication Model: Print Cited Medium: Internet ISSN: 1420-9071 (Electronic) Linking ISSN: 1420682X NLM ISO Abbreviation: Cell Mol Life Sci Subsets: MEDLINE
- Publication Information:
Publication: Basel : Springer
Original Publication: Basel ; Boston : Birkhauser, c1997-
- Subject Terms:
- Abstract:
Although endogenous retroviruses are ubiquitous features of all mammalian genomes, the process of initial germ line invasion and subsequent inactivation from a pathogenic element has not yet been observed in a wild species. Koala retrovirus (KoRV) provides a unique opportunity to study this process of endogenisation in action as it still appears to be spreading through the koala population. Ongoing expression of the endogenous sequence and consequent high levels of viraemia have been linked to neoplasia and immunosuppression in koalas. This apparently recent invader of the koala genome shares a remarkably close sequence relationship with the pathogenic exogenous Gibbon ape leukaemia virus (GALV), and comparative analyses of KoRV and GALVare helping to shed light on how retroviruses in general adapt to a relatively benign or at least less pathogenic existence within a new host genome. (Part of a multi-author review).
- Number of References:
63
- Publication Date:
Date Created: 20080927 Date Completed: 20090119 Latest Revision: 20240530
- Publication Date:
20240530
- Accession Number:
PMC11131744
- Accession Number:
10.1007/s00018-008-8499-y
- Accession Number:
18818870
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