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Coevolution of endogenous betaretroviruses of sheep and their host.
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- Author(s): Arnaud F;Arnaud F; Varela M; Spencer TE; Palmarini M
- Source:
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2008 Nov; Vol. 65 (21), pp. 3422-32.
- Publication Type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
- Language:
English
- Additional Information
- Source:
Publisher: Springer Country of Publication: Switzerland NLM ID: 9705402 Publication Model: Print Cited Medium: Internet ISSN: 1420-9071 (Electronic) Linking ISSN: 1420682X NLM ISO Abbreviation: Cell Mol Life Sci Subsets: MEDLINE
- Publication Information:
Publication: Basel : Springer
Original Publication: Basel ; Boston : Birkhauser, c1997-
- Subject Terms:
Host-Pathogen Interactions*/
genetics;
Betaretrovirus/
*physiology ;
Retroviridae Infections/
*veterinary ;
Sheep/
*virology ;
Sheep Diseases/
*virology;
Amino Acid Sequence ;
Animals ;
Betaretrovirus/
genetics ;
Betaretrovirus/
pathogenicity ;
Cell Transformation, Viral/
genetics ;
Cell Transformation, Viral/
physiology ;
Embryonic Development/
physiology ;
Evolution, Molecular ;
Female ;
Gene Expression Regulation, Viral ;
Genes, Viral ;
Models, Molecular ;
Molecular Sequence Data ;
Morphogenesis ;
Placenta/
virology ;
Placentation ;
Pregnancy ;
Protein Conformation ;
Proviruses/
genetics ;
Proviruses/
physiology ;
Pulmonary Adenomatosis, Ovine/
virology ;
Retroviridae Infections/
virology ;
Retroviridae Proteins, Oncogenic/
genetics ;
Retroviridae Proteins, Oncogenic/
physiology ;
Selection, Genetic ;
Sequence Alignment ;
Sequence Homology, Amino Acid ;
Sheep/
embryology ;
Species Specificity ;
Tumor Virus Infections/
veterinary ;
Tumor Virus Infections/
virology ;
Viral Interference - Abstract:
Sheep betaretroviruses offer a unique model system to study the complex interaction between retroviruses and their host. Jaagsiekte sheep retrovirus (JSRV) is a pathogenic exogenous retrovirus and the causative agent of ovine pulmonary adenocarcinoma. The sheep genome contains at least 27 copies of endogenous retroviruses (enJSRVs) highly related to JSRV. enJSRVs have played several roles in the evolution of the domestic sheep as they are able to block the JSRV replication cycle and play a critical role in sheep conceptus development and placental morphogenesis. Available data strongly suggest that some dominant negative enJSRV proviruses (i.e. able to block JSRV replication) have been positively selected during evolution. Interestingly, viruses escaping the transdominant enJSRV loci have recently emerged (less than 200 years ago). Thus, endogenization of these retroviruses may still be occurring today. Therefore, sheep provide an exciting and unique system to study retrovirus-host coevolution. (Part of a multi-author review).
- Number of References:
73
- Grant Information:
R01 HD052745 United States HD NICHD NIH HHS; HD052745 United States HD NICHD NIH HHS
- Accession Number:
0 (Retroviridae Proteins, Oncogenic)
- Publication Date:
Date Created: 20080927 Date Completed: 20090119 Latest Revision: 20240530
- Publication Date:
20240530
- Accession Number:
PMC4207369
- Accession Number:
10.1007/s00018-008-8500-9
- Accession Number:
18818869
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