Association of urinary bisphenol A concentration with medical disorders and laboratory abnormalities in adults.

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  • Additional Information
    • Source:
      Publisher: American Medical Association Country of Publication: United States NLM ID: 7501160 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-3598 (Electronic) Linking ISSN: 00987484 NLM ISO Abbreviation: JAMA Subsets: MEDLINE
    • Publication Information:
      Original Publication: Chicago : American Medical Association, 1960-
    • Subject Terms:
      Environmental Monitoring*; Biomarkers/*urine ; Cardiovascular Diseases/*epidemiology ; Diabetes Mellitus, Type 2/*epidemiology ; Environmental Pollutants/*toxicity ; Environmental Pollutants/*urine ; Liver Diseases/*epidemiology ; Phenols/*toxicity ; Phenols/*urine; Adult ; Aged ; Benzhydryl Compounds ; Biomarkers/blood ; Blood Glucose ; Cardiovascular Diseases/blood ; Cardiovascular Diseases/urine ; Chronic Disease ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/urine ; Epidemiological Monitoring ; Female ; Health Status ; Humans ; Inflammation ; Insulin Resistance ; Lipids/blood ; Liver Diseases/blood ; Liver Diseases/urine ; Liver Function Tests ; Male ; Middle Aged ; Nutrition Surveys ; Obesity/blood ; Obesity/epidemiology ; Obesity/urine ; Regression Analysis ; Respiratory Tract Diseases/blood ; Respiratory Tract Diseases/epidemiology ; Respiratory Tract Diseases/urine ; United States
    • Abstract:
      Context: Bisphenol A (BPA) is widely used in epoxy resins lining food and beverage containers. Evidence of effects in animals has generated concern over low-level chronic exposures in humans.
      Objective: To examine associations between urinary BPA concentrations and adult health status.
      Design, Setting, and Participants: Cross-sectional analysis of BPA concentrations and health status in the general adult population of the United States, using data from the National Health and Nutrition Examination Survey 2003-2004. Participants were 1455 adults aged 18 through 74 years with measured urinary BPA and urine creatinine concentrations. Regression models were adjusted for age, sex, race/ethnicity, education, income, smoking, body mass index, waist circumference, and urinary creatinine concentration. The sample provided 80% power to detect unadjusted odds ratios (ORs) of 1.4 for diagnoses of 5% prevalence per 1-SD change in BPA concentration, or standardized regression coefficients of 0.075 for liver enzyme concentrations, at a significance level of P < .05.
      Main Outcome Measures: Chronic disease diagnoses plus blood markers of liver function, glucose homeostasis, inflammation, and lipid changes.
      Results: Higher urinary BPA concentrations were associated with cardiovascular diagnoses in age-, sex-, and fully adjusted models (OR per 1-SD increase in BPA concentration, 1.39; 95% confidence interval [CI], 1.18-1.63; P = .001 with full adjustment). Higher BPA concentrations were also associated with diabetes (OR per 1-SD increase in BPA concentration, 1.39; 95% confidence interval [CI], 1.21-1.60; P < .001) but not with other studied common diseases. In addition, higher BPA concentrations were associated with clinically abnormal concentrations of the liver enzymes gamma-glutamyltransferase (OR per 1-SD increase in BPA concentration, 1.29; 95% CI, 1.14-1.46; P < .001) and alkaline phosphatase (OR per 1-SD increase in BPA concentration, 1.48; 95% CI, 1.18-1.85; P = .002).
      Conclusion: Higher BPA exposure, reflected in higher urinary concentrations of BPA, may be associated with avoidable morbidity in the community-dwelling adult population.
    • Comments:
      Comment in: JAMA. 2008 Sep 17;300(11):1353-5. (PMID: 18799451)
      Comment in: JAMA. 2009 Feb 18;301(7):720-1; author reply 721-2. (PMID: 19224743)
      Comment in: JAMA. 2009 Feb 18;301(7):720; author reply 721-2. (PMID: 19224744)
      Comment in: JAMA. 2009 Feb 18;301(7):720; author reply 721-2. (PMID: 19224745)
    • Accession Number:
      0 (Benzhydryl Compounds)
      0 (Biomarkers)
      0 (Blood Glucose)
      0 (Environmental Pollutants)
      0 (Lipids)
      0 (Phenols)
      MLT3645I99 (bisphenol A)
    • Publication Date:
      Date Created: 20080919 Date Completed: 20080924 Latest Revision: 20220408
    • Publication Date:
      20231215
    • Accession Number:
      10.1001/jama.300.11.1303
    • Accession Number:
      18799442