Total cerebral blood flow in relation to cognitive function: the Rotterdam Scan Study.

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  • Author(s): Poels MM;Poels MM; Ikram MA; Vernooij MW; Krestin GP; Hofman A; Niessen WJ; van der Lugt A; Breteler MM
  • Source:
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism [J Cereb Blood Flow Metab] 2008 Oct; Vol. 28 (10), pp. 1652-5. Date of Electronic Publication: 2008 Jun 25.
  • Publication Type:
    Journal Article; Research Support, Non-U.S. Gov't
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: SAGE Publications Country of Publication: United States NLM ID: 8112566 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-7016 (Electronic) Linking ISSN: 0271678X NLM ISO Abbreviation: J Cereb Blood Flow Metab Subsets: MEDLINE
    • Publication Information:
      Publication: 2016- : Thousand Oaks, CA : SAGE Publications
      Original Publication: New York : Raven Press, c1981-
    • Subject Terms:
      Cerebrovascular Circulation* ; Magnetic Resonance Angiography* ; Magnetic Resonance Imaging*; Cognition Disorders/*pathology ; Cognition Disorders/*physiopathology; Aged ; Atrophy ; Brain/blood supply ; Brain/pathology ; Cognition ; Cohort Studies ; Female ; Humans ; Male ; Middle Aged ; Netherlands ; Neuropsychological Tests
    • Abstract:
      Cerebral hypoperfusion has been associated with worse cognitive function. We investigated the association between cerebral blood flow and cognition and whether this association is independent of brain volume. In 892 participants, aged 60 to 91 years, of the population-based Rotterdam Scan study, we measured total cerebral blood flow (tCBF) and brain volume using magnetic resonance imaging. Lower tCBF was associated with worse information-processing speed, executive function, and global cognition. However, after correcting tCBF for brain volume, these associations disappeared. The association between tCBF and cognition may be mediated or confounded by brain atrophy. Future studies on tCBF should take into account brain atrophy.
    • Publication Date:
      Date Created: 20080626 Date Completed: 20081017 Latest Revision: 20220321
    • Publication Date:
      20240829
    • Accession Number:
      10.1038/jcbfm.2008.62
    • Accession Number:
      18575459