Influence of retinoids on skin fibroblasts metabolism in vitro.

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  • Additional Information
    • Source:
      Publisher: Polski Towarzystwo Farmaceutyczne Country of Publication: Poland NLM ID: 2985167R Publication Model: Print Cited Medium: Print ISSN: 0001-6837 (Print) Linking ISSN: 00016837 NLM ISO Abbreviation: Acta Pol Pharm Subsets: MEDLINE
    • Publication Information:
      Publication: Warszawa : Polski Towarzystwo Farmaceutyczne
      Original Publication: Warszawa [194-]-
    • Subject Terms:
      Fibroblasts/*drug effects ; Keratolytic Agents/*pharmacology ; Skin/*drug effects ; Tretinoin/*pharmacology; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Cells, Cultured ; Dose-Response Relationship, Drug ; Fibroblasts/metabolism ; Gene Expression Regulation/drug effects ; Humans ; In Vitro Techniques ; Keratolytic Agents/administration & dosage ; Matrix Metalloproteinases/drug effects ; Matrix Metalloproteinases/metabolism ; Skin/metabolism ; Tretinoin/administration & dosage
    • Abstract:
      The most dangerous environmental factor for our skin condition is ultraviolet light radiation. Chronic exposition to ultraviolet light can induce epidermal atrophy, keratosis, depigmentation and dysplasia. In the dermis, UV light causes dramatic up-regulation of extracellular matrix-degrading enzymes. Matrix metalloproteinases (MMPs) are engaged in collagen, elastin and other extracellular matrix components degradation. In addition, to increase level of destructive enzymes, UV light has been shown to decrease collagen production. As a consequence of UV impact on skin, it shows signs of aging including loss of tone and elasticity, increased skin fragility, blood vessels weakness and wrinkles. The most dangerous effect of UV on skin is an increased risk of melanoma and other skin cancers. Retinoids are well known antiaging agents. For many years this vitamin has been used for the prevention and treatment of photoaging. Retinoids abolish cellular atypia, increase compacting of the stratum corneum and reduce skin hyperpigmentation caused by sun light. Recent evidence suggests that retinoids also play a role in the prevention of aging, because of its inhibitory effects on metalloproteinases expression. The aim of this study was to examine if all-trans-retinoic acid (ATRA) effects MMP-1, MMP-2, MMP-3 and MMP-14 gene expression in fibroblasts cultured in vitro.
    • Accession Number:
      0 (Keratolytic Agents)
      5688UTC01R (Tretinoin)
      EC 3.4.24.- (Matrix Metalloproteinases)
    • Publication Date:
      Date Created: 20080610 Date Completed: 20080624 Latest Revision: 20141120
    • Publication Date:
      20221213
    • Accession Number:
      18536179