A murine model for septic arthritis of the temporomandibular joint.

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  • Author(s): Cai XY;Cai XY; Yang C; Zhang ZY; Qiu WL; Ha Q; Zhu M
  • Source:
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons [J Oral Maxillofac Surg] 2008 May; Vol. 66 (5), pp. 864-9.
  • Publication Type:
    Journal Article; Research Support, Non-U.S. Gov't
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: W.B. Saunders Co Country of Publication: United States NLM ID: 8206428 Publication Model: Print Cited Medium: Internet ISSN: 1531-5053 (Electronic) Linking ISSN: 02782391 NLM ISO Abbreviation: J Oral Maxillofac Surg Subsets: MEDLINE
    • Publication Information:
      Original Publication: [Philadelphia, PA : W.B. Saunders Co., c1982-
    • Subject Terms:
      Disease Models, Animal* ; Mice*; Arthritis, Infectious/*microbiology ; Temporomandibular Joint Disorders/*microbiology; Animals ; Arthritis, Infectious/etiology ; Bacteremia/complications ; Mice, Inbred Strains ; Staphylococcal Infections/microbiology ; Staphylococcus aureus ; Synovial Fluid/microbiology ; Temporomandibular Joint Disorders/etiology
    • Abstract:
      Purpose: This study was designed to establish a murine model of hematogenously acquired bacterial arthritis of the temporomandibular joint (TMJ) to investigate the pathogenesis of this rare TMJ infection.
      Materials and Methods: One hundred forty mice were inoculated intravenously with 3 different staphylococcal suspensions. They were sacrificed at intervals between 1 day and 2 months. Bacterial cultures were obtained from peripheral blood, liver, kidney, TMJs, knees, and interphalangeal joints. The TMJs were collected for histopathological examination.
      Results: Staphylococcus aureus, isolated from the joint fluid of a patient with septic arthritis of the TMJ, was recovered from the liver, kidneys, knees, interphalangeal joints, and TMJs of several animals. Blood cultures were negative. Acute septic arthritis of the TMJs was confirmed in several animals as soon as 4 days after inoculation. Histopathology showed severe damage to chondrocytes and collagen fibers in the condyles and discs, leading to extensive degenerative changes. All cultures were negative, and there were no histopathologic changes in animals inoculated with bacteria from the other sources.
      Conclusions: A murine model for hematogenous septic arthritis of the TMJ was successfully developed with S. aureus isolated from a patient with a TMJ infection. The bacteria induced multiple organ and joint infections. Septic arthritis of the TMJ occurred in 21% of the animals inoculated. Onset was rapid. It produced extensive degenerative changes. The study confirms the need for prompt diagnosis and treatment of patients with septic arthritis. The model may prove to be very useful in the study of this rare infection.
    • Publication Date:
      Date Created: 20080422 Date Completed: 20080505 Latest Revision: 20080421
    • Publication Date:
      20240829
    • Accession Number:
      10.1016/j.joms.2007.06.688
    • Accession Number:
      18423272