Continuous glucose monitoring in cystic fibrosis patients according to the glucose tolerance.

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  • Author(s): Moreau F;Moreau F; Weiller MA; Rosner V; Weiss L; Hasselmann M; Pinget M; Kessler R; Kessler L
  • Source:
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme [Horm Metab Res] 2008 Jul; Vol. 40 (7), pp. 502-6. Date of Electronic Publication: 2008 Apr 14.
  • Publication Type:
    Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Thieme Country of Publication: Germany NLM ID: 0177722 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0018-5043 (Print) Linking ISSN: 00185043 NLM ISO Abbreviation: Horm Metab Res Subsets: MEDLINE
    • Publication Information:
      Original Publication: Stuttgart, Thieme.
    • Subject Terms:
      Glucose Tolerance Test*; Blood Glucose/*analysis ; Cystic Fibrosis/*blood ; Glucose Intolerance/*diagnosis ; Monitoring, Physiologic/*methods; Adolescent ; Adult ; Circadian Rhythm ; Cystic Fibrosis/complications ; Female ; Glucose Intolerance/blood ; Glucose Intolerance/complications ; Humans ; Male ; Time Factors
    • Abstract:
      Cystic fibrosis (CF) is associated with a long preclinical state of abnormal glucose tolerance. The aim of this study was (i) to evaluate the profile of glucose tolerance in young adults with CF and (ii) to compare these results with those obtained by a continuous subcutaneous glucose monitoring (CGMS). CF subjects with fasting glycemia inferior to 126 mg/dl were included in the study. An oral glucose tolerance test (OGTT) identified the subjects either with a normal glucose tolerance (NGT), or impaired glucose tolerance (IGT), or diabetes. CGMS (Medtronic) was performed during 3 days to analyze mean glucose level, high glucose excursions, and glucose area under the curve (AUC). Forty-nine patients were included in the study. NGT (n=22), IGT (n=17), and diabetes groups (n=10) were comparable except with regard to age and BMI (p<0.001). HbA1c values in diabetes group were significantly higher (p<0.001) than in NGT and IGT groups. CGMS revealed peaks of glucose values superior to 200 mg/dl at least once after a meal in 8 patients (36%) with NGT, in 9 patients (52%) with IGT, and in all patients with diabetes (p<0.01). Mean CGMS glucose and glucose AUC values increased in patients with diabetes compared to patients with NGT and IGT (p<0.05). Peak of CGMS glucose reached 182+/-60 mg/dl in NGT group despite the normal glucose profile at OGTT. In conclusion, CGMS revealed pathological glucose excursions not only in patients with impaired glucose tolerance at OGTT but also in patients with a normal glycemic profile. CGMS could be a useful tool for the early detection of hyperglycemia in patients with CF.
    • Accession Number:
      0 (Blood Glucose)
    • Publication Date:
      Date Created: 20080417 Date Completed: 20081006 Latest Revision: 20090219
    • Publication Date:
      20221213
    • Accession Number:
      10.1055/s-2008-1062723
    • Accession Number:
      18415892