Triggering receptors expressed on myeloid cells in pulmonary aspiration syndromes.

Publisher: Springer Verlag Country of Publication: United States NLM ID: 7704851 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0342-4642 (Print) Linking ISSN: 03424642 NLM ISO Abbreviation: Intensive Care Med Subsets: MEDLINE

Publication: New York : Springer Verlag
Original Publication: Berlin ; New York, Springer International.

Biomarkers/*metabolism ; Membrane Glycoproteins/*metabolism ; Myeloid Cells/*metabolism ; Pneumonia/*diagnosis ; Pneumonia, Aspiration/*diagnosis ; Receptors, Immunologic/*metabolism; Bronchoalveolar Lavage Fluid/chemistry ; Bronchoalveolar Lavage Fluid/cytology ; Case-Control Studies ; Chi-Square Distribution ; Diagnosis, Differential ; Female ; Humans ; Male ; Middle Aged ; Pneumonia/metabolism ; Pneumonia/microbiology ; Pneumonia, Aspiration/metabolism ; Pneumonia, Aspiration/microbiology ; Prospective Studies ; ROC Curve ; Respiration, Artificial ; Statistics, Nonparametric ; Triggering Receptor Expressed on Myeloid Cells-1

Objective: To investigate the potential role of serum and alveolar soluble triggering receptor expressed on myeloid cells (sTREM-1) as a biological marker of pulmonary aspiration syndromes.
Design: Prospective cohort study.
Setting: University-affiliated intensive care unit.
Patients: Seventy-five patients with pulmonary aspiration and 13 controls receiving mechanical ventilation.
Interventions: Blood and bronchoalveolar lavage (BAL) fluid samples were collected on enrollment. Soluble TREM-1 levels were measured by an enzyme-linked immunosorbent assay.
Measurements and Results: Thirty-eight of 75 participants had documented BAL culture-positive pulmonary aspiration. While circulating levels of sTREM-1 were comparable between those with aspiration syndromes (19.81 +/- 12.09 pg/ml) and controls (15.96 +/- 11.16 pg/ml) (p=0.27), the alveolar levels of sTREM-1 were higher in patients with culture-positive pulmonary aspiration (344.41 +/- 152.82 pg/ml) compared with those culture-negative pulmonary aspiration (142.76 +/- 89.88 pg/ml; p < 0.001). A cut-off value of 250 pg/ml for alveolar sTREM-1 achieved a sensitivity of 65.8% (95% CI 48.6-80.4) and a specificity of 91.9% (95% CI 78.1-98.2) with an area under the curve of 0.87 (95% CI 0.78-0.94).
Conclusions: Alveolar sTREM-1 levels can be a potential biomarker for distinguishing BAL culture-positive from BAL culture-negative pulmonary aspiration.

Comment in: Intensive Care Med. 2008 Jun;34(6):981-4. (PMID: 18392806)

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0 (Biomarkers)
0 (Membrane Glycoproteins)
0 (Receptors, Immunologic)
0 (TREM1 protein, human)
0 (Triggering Receptor Expressed on Myeloid Cells-1)

Date Created: 20080409 Date Completed: 20090108 Latest Revision: 20211020

20231215

10.1007/s00134-008-1087-7

18392807