The relationship between renal injury and change in vitamin D metabolism in aged rats with insulin resistance or type 2 diabetes mellitus.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Author(s): Huang CQ;Huang CQ; Ma GZ; Tao MD; Ma XL; Feng J; Liu QX
  • Source:
    The Journal of international medical research [J Int Med Res] 2008 Mar-Apr; Vol. 36 (2), pp. 289-95.
  • Publication Type:
    Journal Article; Research Support, Non-U.S. Gov't
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Sage Publications Country of Publication: England NLM ID: 0346411 Publication Model: Print Cited Medium: Print ISSN: 0300-0605 (Print) Linking ISSN: 03000605 NLM ISO Abbreviation: J Int Med Res Subsets: MEDLINE
    • Publication Information:
      Publication: Nov. 2012- : London : Sage Publications
      Original Publication: Northampton, Eng., Cambridge Medical Publications ltd.
    • Subject Terms:
      Aging/*metabolism ; Diabetes Mellitus, Experimental/*metabolism ; Diabetes Mellitus, Type 2/*metabolism ; Insulin Resistance/*physiology ; Kidney/*metabolism ; Kidney/*pathology ; Vitamin D/*metabolism; Aging/pathology ; Aging/physiology ; Animals ; Diabetes Mellitus, Experimental/physiopathology ; Diabetes Mellitus, Type 2/physiopathology ; Male ; Rats ; Rats, Wistar
    • Abstract:
      Insulin resistance (IR), IR treated with vitamin D, IR treated with 1alpha-hydroxyvitamin D (1alpha-(OH)D), type 2 diabetes mellitus (T2DM), T2DM treated with vitamin D and T2DM treated with 1alpha-(OH)D were studied in animal models using aged Wistar rats. Glucose infusion rates and levels of urinary albumin (UA), serum 25-hydroxyvitamin D (25-(OH)D) and 1,25-dihydroxyvitamin D (1,25(OH)2D) were measured. T2DM rats had higher UA than IR or normal rats, and levels of 25-(OH)D in all models weresimilar. IR rats had higher 1,25-(OH)2D levels than T2DM rats, and had lower 1,25-(OH)2D levels than normal rats. Treating IR or T2DM rats with vitamin D had no effect on 25-(OH)D or 1,25-(OH)2D. Administration of 1alpha-(OH)D significantly increased 1,25-(OH)2D in IR rats to above-normal levels, and significantly increased 1,25-(OH)2D in T2DM rats to normal levels. In IR or T2DM, abnormal vitamin D metabolism is characterized by 1,25-(OH)2D deficiency and is related to renal injury.
    • Accession Number:
      1406-16-2 (Vitamin D)
    • Publication Date:
      Date Created: 20080403 Date Completed: 20080617 Latest Revision: 20170214
    • Publication Date:
      20221213
    • Accession Number:
      10.1177/147323000803600211
    • Accession Number:
      18380939