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The relationship between renal injury and change in vitamin D metabolism in aged rats with insulin resistance or type 2 diabetes mellitus.
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- Author(s): Huang CQ;Huang CQ; Ma GZ; Tao MD; Ma XL; Feng J; Liu QX
- Source:
The Journal of international medical research [J Int Med Res] 2008 Mar-Apr; Vol. 36 (2), pp. 289-95.- Publication Type:
Journal Article; Research Support, Non-U.S. Gov't- Language:
English - Source:
- Additional Information
- Source: Publisher: Sage Publications Country of Publication: England NLM ID: 0346411 Publication Model: Print Cited Medium: Print ISSN: 0300-0605 (Print) Linking ISSN: 03000605 NLM ISO Abbreviation: J Int Med Res Subsets: MEDLINE
- Publication Information: Publication: Nov. 2012- : London : Sage Publications
Original Publication: Northampton, Eng., Cambridge Medical Publications ltd. - Subject Terms: Aging/*metabolism ; Diabetes Mellitus, Experimental/*metabolism ; Diabetes Mellitus, Type 2/*metabolism ; Insulin Resistance/*physiology ; Kidney/*metabolism ; Kidney/*pathology ; Vitamin D/*metabolism; Aging/pathology ; Aging/physiology ; Animals ; Diabetes Mellitus, Experimental/physiopathology ; Diabetes Mellitus, Type 2/physiopathology ; Male ; Rats ; Rats, Wistar
- Abstract: Insulin resistance (IR), IR treated with vitamin D, IR treated with 1alpha-hydroxyvitamin D (1alpha-(OH)D), type 2 diabetes mellitus (T2DM), T2DM treated with vitamin D and T2DM treated with 1alpha-(OH)D were studied in animal models using aged Wistar rats. Glucose infusion rates and levels of urinary albumin (UA), serum 25-hydroxyvitamin D (25-(OH)D) and 1,25-dihydroxyvitamin D (1,25(OH)2D) were measured. T2DM rats had higher UA than IR or normal rats, and levels of 25-(OH)D in all models weresimilar. IR rats had higher 1,25-(OH)2D levels than T2DM rats, and had lower 1,25-(OH)2D levels than normal rats. Treating IR or T2DM rats with vitamin D had no effect on 25-(OH)D or 1,25-(OH)2D. Administration of 1alpha-(OH)D significantly increased 1,25-(OH)2D in IR rats to above-normal levels, and significantly increased 1,25-(OH)2D in T2DM rats to normal levels. In IR or T2DM, abnormal vitamin D metabolism is characterized by 1,25-(OH)2D deficiency and is related to renal injury.
- Accession Number: 1406-16-2 (Vitamin D)
- Publication Date: Date Created: 20080403 Date Completed: 20080617 Latest Revision: 20170214
- Publication Date: 20221213
- Accession Number: 10.1177/147323000803600211
- Accession Number: 18380939
- Source:
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