Menu
×
Folly Beach Library
9 a.m. - 5:30 p.m.
Phone: (843) 588-2001
Edgar Allan Poe/Sullivan's Island Library
Closed for renovations
Phone: (843) 883-3914
West Ashley Library
9 a.m. – 7 p.m.
Phone: (843) 766-6635
Wando Mount Pleasant Library
9 a.m. – 8 p.m.
Phone: (843) 805-6888
Village Library
9 a.m. - 6 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
9 a.m. – 8 p.m.
Phone: (843) 889-3300
Otranto Road Library
9 a.m. – 8 p.m.
Phone: (843) 572-4094
Mt. Pleasant Library
9 a.m. – 8 p.m.
Phone: (843) 849-6161
McClellanville Library
9 a.m. - 6 p.m.
Phone: (843) 887-3699
Keith Summey North Charleston Library
9 a.m. – 8 p.m.
Phone: (843) 744-2489
John's Island Library
9 a.m. – 8 p.m.
Phone: (843) 559-1945
Hurd/St. Andrews Library
9 a.m. – 8 p.m.
Phone: (843) 766-2546
Miss Jane's Building (Edisto Library Temporary Location)
9 a.m. - 4 p.m.
Phone: (843) 869-2355
Dorchester Road Library
9 a.m. – 8 p.m.
Phone: (843) 552-6466
John L. Dart Library
9 a.m. – 7 p.m.
Phone: (843) 722-7550
Baxter-Patrick James Island
9 a.m. – 8 p.m.
Phone: (843) 795-6679
Main Library
9 a.m. – 8 p.m.
Phone: (843) 805-6930
Bees Ferry West Ashley Library
9 a.m. – 8 p.m.
Phone: (843) 805-6892
Mobile Library
9 a.m. - 5 p.m.
Phone: (843) 805-6909
Today's Hours
Folly Beach Library
9 a.m. - 5:30 p.m.
Phone: (843) 588-2001
Edgar Allan Poe/Sullivan's Island Library
Closed for renovations
Phone: (843) 883-3914
West Ashley Library
9 a.m. – 7 p.m.
Phone: (843) 766-6635
Wando Mount Pleasant Library
9 a.m. – 8 p.m.
Phone: (843) 805-6888
Village Library
9 a.m. - 6 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
9 a.m. – 8 p.m.
Phone: (843) 889-3300
Otranto Road Library
9 a.m. – 8 p.m.
Phone: (843) 572-4094
Mt. Pleasant Library
9 a.m. – 8 p.m.
Phone: (843) 849-6161
McClellanville Library
9 a.m. - 6 p.m.
Phone: (843) 887-3699
Keith Summey North Charleston Library
9 a.m. – 8 p.m.
Phone: (843) 744-2489
John's Island Library
9 a.m. – 8 p.m.
Phone: (843) 559-1945
Hurd/St. Andrews Library
9 a.m. – 8 p.m.
Phone: (843) 766-2546
Miss Jane's Building (Edisto Library Temporary Location)
9 a.m. - 4 p.m.
Phone: (843) 869-2355
Dorchester Road Library
9 a.m. – 8 p.m.
Phone: (843) 552-6466
John L. Dart Library
9 a.m. – 7 p.m.
Phone: (843) 722-7550
Baxter-Patrick James Island
9 a.m. – 8 p.m.
Phone: (843) 795-6679
Main Library
9 a.m. – 8 p.m.
Phone: (843) 805-6930
Bees Ferry West Ashley Library
9 a.m. – 8 p.m.
Phone: (843) 805-6892
Mobile Library
9 a.m. - 5 p.m.
Phone: (843) 805-6909
Patron Login
menu
Item request has been placed!
×
Item request cannot be made.
×
![loading](/sites/all/modules/hf_eds/images/loading.gif)
Reconstructing population exposures to environmental chemicals from biomarkers: challenges and opportunities.
Item request has been placed!
×
Item request cannot be made.
×
![loading](/sites/all/modules/hf_eds/images/loading.gif)
- Author(s): Georgopoulos PG;Georgopoulos PG; Sasso AF; Isukapalli SS; Lioy PJ; Vallero DA; Okino M; Reiter L
- Source:
Journal of exposure science & environmental epidemiology [J Expo Sci Environ Epidemiol] 2009 Feb; Vol. 19 (2), pp. 149-71. Date of Electronic Publication: 2008 Mar 26.- Publication Type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.- Language:
English - Source:
- Additional Information
- Source: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101262796 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-064X (Electronic) Linking ISSN: 15590631 NLM ISO Abbreviation: J Expo Sci Environ Epidemiol Subsets: MEDLINE
- Publication Information: Original Publication: New York, NY : Nature Pub. Group, c2006-
- Subject Terms: Biopharmaceutics*/methods ; Biopharmaceutics*/statistics & numerical data; Biomarkers/*analysis ; Environmental Exposure/*analysis ; Environmental Pollutants/*administration & dosage; Algorithms ; Bayes Theorem ; Biomarkers/chemistry ; Biomarkers/urine ; Environmental Pollutants/chemistry ; Environmental Pollutants/pharmacokinetics ; Environmental Pollutants/urine ; Humans ; Monte Carlo Method ; Population Groups/classification ; Population Groups/statistics & numerical data ; Risk Assessment ; Stochastic Processes ; Time Factors
- Abstract: A conceptual/computational framework for exposure reconstruction from biomarker data combined with auxiliary exposure-related data is presented, evaluated with example applications, and examined in the context of future needs and opportunities. This framework employs physiologically based toxicokinetic (PBTK) modeling in conjunction with numerical "inversion" techniques. To quantify the value of different types of exposure data "accompanying" biomarker data, a study was conducted focusing on reconstructing exposures to chlorpyrifos, from measurements of its metabolite levels in urine. The study employed biomarker data as well as supporting exposure-related information from the National Human Exposure Assessment Survey (NHEXAS), Maryland, while the MENTOR-3P system (Modeling ENvironment for TOtal Risk with Physiologically based Pharmacokinetic modeling for Populations) was used for PBTK modeling. Recently proposed, simple numerical reconstruction methods were applied in this study, in conjunction with PBTK models. Two types of reconstructions were studied using (a) just the available biomarker and supporting exposure data and (b) synthetic data developed via augmenting available observations. Reconstruction using only available data resulted in a wide range of variation in estimated exposures. Reconstruction using synthetic data facilitated evaluation of numerical inversion methods and characterization of the value of additional information, such as study-specific data that can be collected in conjunction with the biomarker data. Although the NHEXAS data set provides a significant amount of supporting exposure-related information, especially when compared to national studies such as the National Health and Nutrition Examination Survey (NHANES), this information is still not adequate for detailed reconstruction of exposures under several conditions, as demonstrated here. The analysis presented here provides a starting point for introducing improved designs for future biomonitoring studies, from the perspective of exposure reconstruction; identifies specific limitations in existing exposure reconstruction methods that can be applied to population biomarker data; and suggests potential approaches for addressing exposure reconstruction from such data.
- Comments: Comment in: J Expo Sci Environ Epidemiol. 2008 Nov;18(6):535; author reply 536-7. (PMID: 18936758)
- References: Pediatr Res. 2004 Mar;55(3):466-71. (PMID: 14681495)
J Expo Anal Environ Epidemiol. 2004 May;14(3):260-74. (PMID: 15141155)
Eur J Epidemiol. 2006;21(3):167-70. (PMID: 16547830)
Res Rep Health Eff Inst. 2003 Jun;(115):1-72; discussion 73-87. (PMID: 12931845)
J Toxicol Environ Health A. 2003 Dec 12;66(23):2227-52. (PMID: 14612335)
Biometals. 2003 Mar;16(1):41-54. (PMID: 12572663)
Environ Health Perspect. 2002 Mar;110(3):235-40. (PMID: 11882473)
Regul Toxicol Pharmacol. 2002 Apr;35(2 Pt 1):177-97. (PMID: 12052003)
J Toxicol Environ Health B Crit Rev. 2006 Jan-Feb;9(1):63-85. (PMID: 16393870)
J Biochem Mol Toxicol. 2003;17(4):201-6. (PMID: 12898643)
Toxicol Lett. 2004 Mar 21;148(3):153-8. (PMID: 15041065)
J Expo Anal Environ Epidemiol. 2004 May;14(3):204-13. (PMID: 15141149)
Cell Mol Biol (Noisy-le-grand). 2000 Mar;46(2):451-63. (PMID: 10774933)
Stat Methods Med Res. 1995 Sep;4(3):197-217. (PMID: 8548103)
Comput Methods Programs Biomed. 2002 Jan;67(1):67-77. (PMID: 11750948)
J Expo Anal Environ Epidemiol. 2000 Mar-Apr;10(2):145-58. (PMID: 10791596)
J Expo Anal Environ Epidemiol. 2003 May;13(3):187-202. (PMID: 12743613)
Risk Anal. 2007 Aug;27(4):947-59. (PMID: 17958503)
Anal Chem. 2005 May 1;77(9):2875-81. (PMID: 15859605)
IEEE Trans Biomed Eng. 2004 Feb;51(2):273-81. (PMID: 14765700)
J Expo Anal Environ Epidemiol. 2004 Nov;14(6):457-65. (PMID: 15367927)
J Expo Anal Environ Epidemiol. 2005 Jul;15(4):297-309. (PMID: 15367928)
J Anim Sci. 1994 Dec;72(12):3055-65. (PMID: 7759353)
Genome Res. 2003 Nov;13(11):2467-74. (PMID: 14559783)
Med Phys. 2002 May;29(5):848-56. (PMID: 12033581)
J Pharmacokinet Pharmacodyn. 2002 Aug;29(4):403-10; discussion 411-2. (PMID: 12518711)
J Chem Inf Comput Sci. 2003 Nov-Dec;43(6):2106-10. (PMID: 14632462)
Toxicol Lett. 2005 Nov 15;159(2):182-91. (PMID: 15994032)
Environ Health Perspect. 2002 Oct;110 Suppl 5:689-94. (PMID: 12426113)
J Chem Inf Comput Sci. 2004 Nov-Dec;44(6):2061-9. (PMID: 15554676)
Toxicol Sci. 2001 Jun;61(2):374-81. (PMID: 11353146)
J Pharm Biomed Anal. 2005 Oct 4;39(5):1021-30. (PMID: 16040225)
Biophys Chem. 2003 May 1;104(1):249-58. (PMID: 12834843)
J Expo Anal Environ Epidemiol. 1998 Jul-Sep;8(3):407-22. (PMID: 9679220)
Altern Med Rev. 2003 May;8(2):106-28. (PMID: 12777158)
AAPS PharmSci. 1999;1(4):E17. (PMID: 11741213)
Risk Anal. 1998 Jun;18(3):351-63. (PMID: 9722454)
J Pharmacokinet Biopharm. 1995 Feb;23(1):87-100. (PMID: 8576846)
Toxicol Appl Pharmacol. 2004 Dec 1;201(2):166-77. (PMID: 15541756)
Environ Health Perspect. 2000 May;108 Suppl 2:275-82. (PMID: 10807558)
J Pharm Sci. 1997 Jul;86(7):840-5. (PMID: 9232526)
Toxicol Ind Health. 1996 Mar-Apr;12(2):153-63. (PMID: 8794529)
Environ Health Perspect. 2006 Nov;114(11):1755-62. (PMID: 17107864)
J Pharm Sci. 1996 May;85(5):505-10. (PMID: 8742942)
Stat Med. 2006 Apr 30;25(8):1355-67. (PMID: 16100739)
Toxicol Lett. 2002 Sep 5;135(1-2):51-9. (PMID: 12243863)
J Pharmacokinet Pharmacodyn. 2002 Jun;29(3):271-307. (PMID: 12449499)
BMC Bioinformatics. 2005 Sep 12;6:225. (PMID: 16156896)
Environ Mol Mutagen. 2004;43(4):258-64. (PMID: 15141365)
J Pharmacokinet Pharmacodyn. 2005 Feb;32(1):85-107. (PMID: 16175312)
Toxicol Appl Pharmacol. 1984 Mar 30;73(1):8-15. (PMID: 6200956)
Biol Pharm Bull. 1995 Dec;18(12):1787-9. (PMID: 8787810)
Chem Pharm Bull (Tokyo). 1989 Apr;37(4):1035-8. (PMID: 2766405)
Environ Health Perspect. 2005 Feb;113(2):192-200. (PMID: 15687057)
J Biochem Mol Toxicol. 2005;19(4):276-7. (PMID: 16173064)
Environ Res. 1995 Nov;71(2):99-108. (PMID: 8977618)
Drug Metab Dispos. 2001 Sep;29(9):1201-4. (PMID: 11502728)
IEEE Trans Neural Netw. 1996;7(4):969-84. (PMID: 18263491)
Curr Drug Discov Technol. 2005 Jun;2(2):99-113. (PMID: 16472234)
J Expo Anal Environ Epidemiol. 1999 Sep-Oct;9(5):427-34. (PMID: 10554145)
Pharm Res. 1999 Jun;16(6):944-8. (PMID: 10397618)
Toxicol Sci. 2002 Mar;66(1):34-53. (PMID: 11861971)
Artif Intell Med. 2005 Sep-Oct;35(1-2):135-45. (PMID: 16051476)
J Expo Anal Environ Epidemiol. 2005 May;15(3):271-81. (PMID: 15340359)
Exp Biol Med (Maywood). 2007 Jan;232(1):3-13. (PMID: 17202581)
Anticancer Res. 1994 Nov-Dec;14(6A):2375-7. (PMID: 7825975)
J Expo Sci Environ Epidemiol. 2007 Nov;17(7):591-603. (PMID: 17108893)
J Expo Anal Environ Epidemiol. 2001 Jul-Aug;11(4):279-85. (PMID: 11571607)
J Toxicol Environ Health A. 2006 Sep;69(18):1727-56. (PMID: 16864423)
Int J Hyg Environ Health. 2007 May;210(3-4):229-38. (PMID: 17157561)
Risk Anal. 2002 Aug;22(4):689-99. (PMID: 12224743)
Regul Toxicol Pharmacol. 2007 Feb;47(1):1-18. (PMID: 16901594)
Pharm Res. 2005 Aug;22(8):1247-58. (PMID: 16078134)
Annu Rev Nutr. 1997;17:37-50. (PMID: 9240918)
Med Phys. 2006 Feb;33(2):342-53. (PMID: 16532939)
J Expo Anal Environ Epidemiol. 1999 Sep-Oct;9(5):369-80. (PMID: 10554140)
Comput Methods Programs Biomed. 1989 Jul;29(3):191-5. (PMID: 2776455)
Environ Health Perspect. 2003 Oct;111(13):1640-8. (PMID: 14527844)
Risk Anal. 2000 Oct;20(5):591-602. (PMID: 11110207)
Ann N Y Acad Sci. 2004 Mar;1012:142-52. (PMID: 15105261)
Regul Toxicol Pharmacol. 2007 Feb;47(1):96-109. (PMID: 17030369)
J Comput Biol. 2005 Sep;12(7):971-9. (PMID: 16201916)
Risk Anal. 2008 Jun;28(3):723-40. (PMID: 18643828)
J Pharmacokinet Pharmacodyn. 2005 Aug;32(3-4):401-18. (PMID: 16320100)
Biostatistics. 2006 Jan;7(1):71-84. (PMID: 15972888)
Risk Anal. 2006 Aug;26(4):925-43. (PMID: 16948686)
Environ Health Perspect. 2005 Jun;113(6):775-81. (PMID: 15929903)
Stat Med. 2003 May 15;22(9):1365-81. (PMID: 12704603)
Environ Health Perspect. 2006 Nov;114(11):1763-9. (PMID: 17107865)
J Expo Sci Environ Epidemiol. 2006 Jan;16(1):19-29. (PMID: 16007116)
J Toxicol Environ Health B Crit Rev. 2006 Nov-Dec;9(6):457-83. (PMID: 17090483)
Altern Med Rev. 1998 Aug;3(4):262-70. (PMID: 9727078)
Environ Health Perspect. 1995 Apr;103 Suppl 3:45-8. (PMID: 7635111)
Phys Med Biol. 2004 Nov 21;49(22):5087-99. (PMID: 15609560)
Curr Top Med Chem. 2006;6(15):1593-607. (PMID: 16918471)
J Expo Anal Environ Epidemiol. 2005 Sep;15(5):388-97. (PMID: 15602583)
Biosystems. 2007 Mar;88(1-2):56-75. (PMID: 16870322)
J Biol Chem. 2006 Mar 17;281(11):7364-73. (PMID: 16407288) - Grant Information: P30 ES005022 United States ES NIEHS NIH HHS; P30 ES005022-22 United States ES NIEHS NIH HHS; P30 ES 005022 United States ES NIEHS NIH HHS
- Accession Number: 0 (Biomarkers)
0 (Environmental Pollutants) - Publication Date: Date Created: 20080328 Date Completed: 20090615 Latest Revision: 20211020
- Publication Date: 20240628
- Accession Number: PMC3068528
- Accession Number: 10.1038/jes.2008.9
- Accession Number: 18368010
- Source:
Contact CCPL
Copyright 2022 Charleston County Public Library Powered By EBSCO Stacks 3.3.0 [350.3] | Staff Login
No Comments.