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John L. Dart Library
Closed for Maintenance
Phone: (843) 722-7550
West Ashley Library
9 a.m. - 5 p.m.
Phone: (843) 766-6635
Folly Beach Library
9 a.m. - 2 p.m.
*open the 2nd and 4th Saturday
*open the 2nd and 4th Saturday
Phone: (843) 588-2001
Edgar Allan Poe/Sullivan's Island Library
Closed for renovations
Phone: (843) 883-3914
Wando Mount Pleasant Library
9 a.m. - 5 p.m.
Phone: (843) 805-6888
Village Library
9 a.m. - 1 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
9 a.m. - 5 p.m.
Phone: (843) 889-3300
Otranto Road Library
9 a.m. - 5 p.m.
Phone: (843) 572-4094
Mt. Pleasant Library
9 a.m. – 5 p.m.
Phone: (843) 849-6161
McClellanville Library
9 a.m. – 1 p.m.
Phone: (843) 887-3699
Keith Summey North Charleston Library
9 a.m. - 5 p.m.
Phone: (843) 744-2489
John's Island Library
9 a.m. - 5 p.m.
Phone: (843) 559-1945
Hurd/St. Andrews Library
9 a.m. - 5 p.m.
Phone: (843) 766-2546
Miss Jane's Building (Edisto Library Temporary Location)
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Phone: (843) 552-6466
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Phone: (843) 795-6679
Main Library
9 a.m. - 5 p.m.
Phone: (843) 805-6930
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Phone: (843) 805-6892
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Closed
Phone: (843) 805-6909
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Quality of life during treatment with haloperidol or olanzapine in the year following a first psychotic episode
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- Author(s): Strakowski, Stephen M.1 ; Johnson, Jacqueline L.2; DelBello, Melissa P.1; Hamer, Robert M.2; Green, Alan I.3; Tohen, Mauricio4,5; Lieberman, Jeffrey A.2,6; Glick, Ira7; Patel, Jayendra K.8; HGDH Research Group (CORPORATE AUTHOR)
- Source:
Schizophrenia Research. Oct2005, Vol. 78 Issue 2/3, p161-169. 9p.- Subject Terms:
*OLANZAPINE; *ANTIPSYCHOTIC agents; *SEROTONIN antagonists; *QUALITY of life; *BENZODIAZEPINES; *PSYCHOSES; *MENTAL health; *TRANQUILIZING drugs; *HALOPERIDOL; *COMPARATIVE studies; *HEALTH surveys; *LONGITUDINAL method; *RESEARCH methodology; *MEDICAL cooperation; *PAIN; *QUESTIONNAIRES; *RESEARCH; *TIME; *EVALUATION research; *PAIN measurement; *RANDOMIZED controlled trials; *BLIND experiment; *DISEASE progression; *DIAGNOSIS; *THERAPEUTICS - Source:
- Additional Information
- Abstract:
Objectives: Schizophrenia causes significant impairments of quality of life. As treatment approaches have advanced, more attention has been given to re-integrating patients into their psychosocial environments, rather than simply monitoring psychotic symptoms. The development of the second-generation antipsychotics raised hope that these medications would provide better quality of life improvement than conventional antipsychotics. This improvement is particularly relevant early in the course of schizophrenia.Methods: To address these considerations, improvements in measures of general health and social function (determined using the SF-36) were assessed in 195 patients with first-episode schizophrenia for up to one year following randomization to either olanzapine or haloperidol in a double blind clinical trial. We hypothesized that olanzapine would demonstrate better improvement on these measures than haloperidol. In order to test this hypothesis, we used a repeated measure model with SF-36 scores as the outcome, and treatment group, time, time2, time-by-treatment group interaction, and time2-by-treatment group interaction as fixed effects.Results: Both treatments demonstrated similar changes on the SF-36. Independent of treatment, patients demonstrated significant improvements in most of the SF-36 subscales, which approached normative scores by the end of one year of treatment. Forty-six of 100 olanzapine-treated patients and 37 of 95 haloperidol-treated patients completed the one year of this study (p<.4).Conclusions: These results suggest an important initial treatment goal for patients with new onset schizophrenic disorders, namely that they can expect to recover significant quality of life and social function at least initially in treatment. [ABSTRACT FROM AUTHOR] - Abstract: Copyright of Schizophrenia Research is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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